各型肝病患者血浆内皮素水平的检测和临床意义  

Study on the Change of Plasma Endothelin Level in Different Types of Liver Diseases

作　　者：叶晓光[1] 陈志伟[1] 黄凤照[1] 罗润齐[1] 

机构地区：[1]广州医学院第二附属医院传染病科,广州510260

出　　处：《广州医学院学报》1999年第3期20-22,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的：为探讨内皮素（ＥＴ）在各型肝病患者中的变化规律。方法：采用非平衡竞争性放射免疫法测定血浆中ＥＴ水平。结果１５１例肝病患者中的ＥＴ水平（ｘ±ｓ）分别为：急性肝炎２６． ８２±３．３９ｐｇ／ｍｌ；慢性肝炎 ５２．８５±３．６９ｐｇ／ｍｌ；肝硬化 ６８．１４±６．８１ｐｇ／ｍｌ；原发性肝癌 ７７．９９±０．０５ｐｇ／ｍｌ。显示除急性肝炎外，其余各型肝病的 ＥＴ水平与正常（３２．２２± ０ ６５ｐｇ／ｍｌ）比较有显著性升高（Ｐ＜０．０１）。各型之间有显著性异（Ｐ＜０．０１）。肝硬化失代偿期与代偿期有显著性差异（ Ｐ＜ ０． ０５）。结论： ＥＴ随着肝脏损害程度加重而升高，与肝病的慢性化程度相关， ＥＴ越高，预后越差。检测ＥＴ水平对肝病的临床诊断和预后的估计有一定的作用。Objective: In order to study the change of the endothelin(ET) level in different types of liver diseases. Methods: The method of non-equation competition radioimmunoassay was used to detect the plasma ET level. Results: 151 patients plasma ET levels(x± s )were detected, that of acute hepatitis was 26. 82±3.39pg/ml; that of chronic hepatitis was 52. 85± 3.69pg/ml; that of liver cirrhosis was 68.14±6.81pg/ml; and that of liver cancer was 77.99±0.05pg/ml. Except for that of acute hepatitis, that of other liver diseases were Obviously higher than that of control group (32.22± 0.65pg/ml, P < 0. 01 ). Among the liver diseases of different types, significant difference was observed(p < 0. 01 ). The ET level in decompensation phase of cirrhosis was higher than that in compensation phase(P < 0. 05). Conclusion: ET level increases with the seventy,of the liver diseases,and it may be related to the extent of chronicity. Higher ET level may indicate worse prognosis. In summary, the detection of ET level may have some significance in the diagnosis and the estimation of prognosis of liver diseases.

关 键 词：内皮素 检测 肝脏疾病 

分 类 号：R575[医药卫生—消化系统]