分形理论在宫颈癌细胞核形态研究中的应用  

Application of Fractal Theory on Study Nuclear Shape of Cervix Carcinoma

作　　者：俞帆[1] 陈钢[1] 欧阳明[1] 田敬学[2] 李萍 

机构地区：[1]云南大学实验中心,昆明650091 [2]昆明市第一人民医院病理科,昆明650011 [3]昆明铁路中心医院病理科,昆明650032

出　　处：《云南大学学报（自然科学版）》1998年第S2期347-350,共4页Journal of Yunnan University(Natural Sciences Edition)

摘　　要：将分形理论应用于宫颈癌细胞核的研究中，选取不同变异程度的宫颈癌及正常组织切片标本，通过图象分析系统，采用数盒子的方法算出细胞核边界的分维值，所得结果用Ｎｅｗｍａｎ－ｋｅｕｌｓ方法进行检验，结果表明：所检测的细胞核边界的分维值均大于其拓扑值１，即它们都是分形结构；不同变异程度的宫颈癌细胞核边界的分维值均大于正常细胞核边界的分维值，Ⅲ级宫颈癌细胞核边界的分维值与正常的相比有显著差异（Ｐ＜０．０１）．In this research fractal geometry was used to analyse the nuclear shape of cervix carcinoma. Nuclei that had different variation degrees were chosen, the fractal dimensions of their boundaries were measured through box - counting method. Results were evaluated using Newman - keuls test.This study showed that the fractal dimensions of all the cell nuclei were greater than their topological dimensions of 1. So their nuclear boundaries are fractal structures. The fractal dimensions of nuclei of different variation degrees were greater than that of normal nuclei. There had significant difference between the fractal dimensions of nuclei of Ⅲ cervix carcinoma and for of normal (P< 0.01).

关 键 词：分形 分维 图象分析 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]