可手术乳腺癌内分泌受体状态对预测近期复发的意义  

Predictive Value of Hormone Receptor Status for Early Recurrence in Operable Breast Cancer

作　　者：石晓毅[1] 沈明[1] 王玲娟[1] 

机构地区：[1]北京铁路总医院,100038

出　　处：《中国肿瘤临床与康复》1998年第S1期9-10,8,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的为了调查可手术乳腺癌病人术后近期复发与内分泌受体状态的相关性。材料和方法对1985-1988年间76例Ⅰ、Ⅱ期乳腺癌改良根治手术病人进行专人调查，注重询问术后36个月内的近期复发病人，探讨复发和未复发病例的雌激素受体（ER）和孕酮受体（PR）的状态。结果确认16例术后36个月内出现复发，近期复发率为21％（16／76）。16例复发的ER、PR同时呈（＋）和（-）的比率分别为29％和57％；而60例未复发的ER、PR同时呈（＋）和（-）的比率分别为50％和40％；两组之间具有显著差异（P＜0.01）。在复发组中单独PR呈（＋）和（-）的比率分别为36％和64％；而未复发组单独PR呈（＋）和（-）的比率分别为51．9％和48．1％，两组之间也具有显著差异（P＜0．05）。结论表明可手术乳腺癌内分泌状态ER、PR同时呈（-）病人较其同时呈（+）者抑或单独PR呈（-）者具有近期易复发倾向，其预后更劣。因而作者认为PR状态是另一个主要的预后因素。提议：应把PR（-）肿瘤病人列入高危人群，并作为术后3年内定期复诊主要对象之一。? Purpose TO inquire into the postoperative early recurrent patients of operable breast Cancer related to hormone receptor status. Methods For the seventy-six cases of the Ⅰ、Ⅱstage breast Cancer (during 1985-1988) Carried out modified radical mastectomy,Pay attention to investigation and study recurrent condition about postoperative patients of the less than 36 months,to analized the ER and PR Status of recurrence group and Unrecurrence group. Results in postoperative 36 months,there were early recurrence rates of 21 % (16/76). The ER、PR revealed simultaneously positive and negative status were 29% and 57% respectively in this early recurrence group; but the ER、PR revealed simultaneously positive and negative status were 50% and 40% respectively in 60cases of the unrecurrence group, there were significant different between recurrence group and unrecurrence group (P<0. 01 ). Single PR revealed positive and negative status were 36% and 64%respectively in recurrence group; but single PR revealed positive and negative status were 5l. 9% and 48. 1 % respectively in unrecurrence group, there were significant different between the two groups (P<0. 05). Conclusion The ER、 PR revealed simultaneously negative patients is easily induce early recurrence than those revealed simultaneously positive one's or single PR negative patients is poor prognosis. Therefore, we suggest that the PR negative patients belongs to high risk group, the PR status is another independent prognostic factor was considered.〔

关 键 词：可手术乳腺癌 内分泌受体 近期复发 预后 

分 类 号：R737.9[医药卫生—肿瘤]