兰索拉唑预防急性脑血管病性应激性溃疡的前瞻性对照研究  

A prospective study of lansoprazole prevention stress ulcers in acute cerebral vascular disease

作　　者：陈剑群[1] 耿德勤[2] 费素娟[1] 陈玉林[1] 胡翠虹 

机构地区：[1]徐州医学院附属医院消化内科,江苏省徐州市221002 [2]徐州医学院附属医院神经内科,江苏省徐州市221002

出　　处：《世界华人消化杂志》1998年第S2期141-142,共2页World Chinese Journal of Digestology

摘　　要：目的观察兰索拉唑对急性脑血管病伴发的应激性溃疡预防作用方法选择急性脑血管病患者104例（脑梗塞72例，脑出血32例），随机分成两组：兰索拉唑组53例，雷尼替丁组51例，观察两组患者中应激性溃疡发生率及死亡率，两种药物的副反应，对胃液pH的影响。结果兰索拉唑能预防应激性溃疡的发生和提高胃液酸碱度，兰索拉唑的副反应少于雷尼替丁，但与雷尼替丁比较病死率无显著性差异（P＞0．05）。结论兰索拉唑抑制急性脑血管病患者的胃酸分泌，改变胃内酸碱度，预防应激性溃疡的发生，而且副反应少，口服方便．AIM To investigate the preventive effects of lansoprazole on stress ulcer in acute cerebral disease.METHODS 104 patients with acute cerebral vascular disease were randomised to divided into two groups: 53 patients were given lansoprazole (30 mg, po. qn), and another 51 patients were given ranitidine (300 mg, po,qn). The presentation and death of stress ulcers, and side effects in two drugs were compared- In the lansoprazole group, there were acute cerebral ischemic infarction 36 cases and cerebral hemorrhage 17 cases; and in the ranitione group, acute ischemic stroke 40 cases and cerebral hemorrhage 11 cases; according to 'Chinese classification and standards of cerebrovascular disease',all completed CT or MRl after stroke.RESULTS bensoprazole was very efthetive to prevent the stress ulcer in petients with acute cerebral vascular disease, suppressed to secret gastric acid and raised the degree of PH, and its side effects were lesser than ranitidine; but the rates of death was similar to two drugs (3 .8% vs 5. 9%, P>0.05).CONCLUSION Lansoprazole can suppress the scretion of gastric acid, Change pH of gastric fluid and prevent.Creating from acute stroke, and less side efthets of oral simply

关 键 词：脑血管意外 消化性溃疡/预防和控制 兰索拉唑/治疗作用 兰素拉唑/副作用 胃酸/分泌 

分 类 号：R574.1[医药卫生—消化系统]