胃肠道癌患者围手术期应用西咪替丁对NK细胞的影响  

Effects of perioperative cimetidine administration on natural killer cells in patients with gastrointestinal cancer

作　　者：李雁[1] 白德骄[1] 王坤[1] 杨国梁[1] 袁宏银[1] 

机构地区：[1]湖北医科大学附属第二医院肿瘤科,湖北省武汉市430071

出　　处：《世界华人消化杂志》1998年第S2期224-225,共2页World Chinese Journal of Digestology

摘　　要：目的探讨西咪替丁（Cim）对胃肠道癌患者围手术期NK细胞的影响．方法胃肠道癌患者49例（胃癌6例，结肠癌3例，直肠癌16例）以围手术期是否应用Cim（400mg，3次／d，po，术前7d～10d；600mg，2次／d，iv，至术后d10）分治疗组和对照组.于入院时，手术前，术后d2，d10各抽取患者的外周血1次，动态检测NK细胞（鼠抗人CD57单克隆抗体）的变化．结果与常相比两组治疗前NK细胞数量均见降低．治疗组术后NK百分率即明显升高，至术后d10即达正常水平.对照组术后NK无明显升高，术后d10仍明显低于正常，差异有高度显著性（P＜0．01）治疗组入院时、手术前、术后d2，d10NK细胞的百分率（％）分别为14．60±3．91，15．640±3．41，17．40±3．28，20．68±4．13；对照组分别为14．88±2．76，13.17±2．43，14．50±2．77，15，67±2．55.结论围手术应用Cim有助于NK细胞恢复.这可能有利于降低局部复发和转移．AIM To study the effects of perioperative cimetidine on NK cells in gastrointestinal cancer patients.METHODS Fourty-nine patients were divided into treatment group which took cimetidine periopratvely,and control group which did not take the medicine. NK cells were measured in the perioperative period. RESULTS Both groups had lower NK percentages than normal before treatment. NK cell percentages (%) at admission, before operation, on the second ostoperative day, and on the tenth postoperative day were 14.60 ±3.91,15.64 ± 3.41, 17.40± 3.28,20.68 ± 4. 13, respectively,for treatment group, and 14.88 ±2.76, 13. 17±2.43,14.50± 2. 77, 15. 67 ±2. 55, respectively, for control group.The differences were statistically very significant (P<0.01).CONCIJSION Perioperative cimetidine application can restore NK cells, which may be beneficial to reducing recurrence and metastasis.

关 键 词：胃肠肿瘤/药物疗法 胃肠肿瘤/外科学 西咪替丁 杀伤细胞 自然 

分 类 号：R735[医药卫生—肿瘤]