肝病患者LN,PCⅢ,Ⅳ-C及PLD变化的意义  

Alterations of LN, PC Ⅲ, Ⅳ-C and PLD in patients with liver diseases

作　　者：黄月红[1] 王小众[1] 陈治新[1] 陈道纯[1] 林谷珍[1] 

机构地区：[1]福建医科大学附属协和医院消化内科,福建省福州市350001

出　　处：《世界华人消化杂志》1998年第S2期235-236,共2页World Chinese Journal of Digestology

摘　　要：目的探讨慢性肝病患者血清LN，PCⅢ，Ⅳ－C及PLD变化的临床意义．方法慢性肝病患者99例，其中慢性HBV感染30例，肝硬变40例，肝癌29例及正常对照30例进行研究.血清LN，PCⅢ及Ⅳ－C含量用放射免疫测定，血清PLD采用生化比色法测定.结果肝硬变及肝癌患者血清LN，PCⅢ，Ⅳ－C，PLD均显著高于正常组及慢性HBV感染织（P均＜0．01），慢性HBV感染织PCⅢ也较正常组为高（P＜0．01），肝硬变患者血清PCⅢ，Ⅳ－C含量较肝癌组增高（P＜0.05）．肝硬变组各指标单项检测阳性率为PCⅢ＞LN＞Ⅳ－C＞PLD，联合检测以PCⅢ＋LN阳性率为高.肝硬变、肝癌与HBV感染单项指标检测结果存在部分重叠．结论LN，PC-Ⅲ，Ⅳ－C及PLD检测有助于肝硬变患者的临床诊断及慢性HBV感染的趋势判断；PCⅢ＋LN联合检测可提高肝硬变诊断的特异性．AIM To explore the clinical significance of serum type Ⅲprocollagen (PCⅢ), laminin (LN), prolidase (PLD) andtype Ⅳ collagen in patients with liver diseases.METIIODS Nintynine patients with liver diseasesinvolved in this study, including 30 cases of chronic HBVinfection, 40 cases of liver cirrhosis and 29 cases of livercarcinoma Serum levels of LN, PC Ⅲ and Ⅳ-c were.measured by radioimmunoassay. Serum level of PLD wasmeasured by biochemical colorimetric analysis.RESULTS Serum Ievels of LN, PC Ⅲ, Ⅳ-C and PLD inpatients with liver cirrhosis and carcinoma weresignficantly higher than those of normal controls and thepatients with chronic HBV infection (P< 0 .01). Serum PCⅢ level in patients with chronic HBV infeCtion wassignificantly higher than that of normaI controIs (P <0 .01 ). Serum levels of PCⅢ and Ⅳ-C in patients with livercirrhosis were significantIy higher than that of livercarcinoma (P<0 .05). Tbo positive rate of singIe index inliver cirrhosis was PC Ⅲ > LN > Ⅳ-C > PLD in order.Combined determination of PC Ⅲ and LN had a higherpositive rate in petients with liver cirrhosis. There was aconsiderabIe overlap among cirrhosis, carcinrma andchronic HBV infedion in single index determination.CONCLUSION Serum levels of LN, PCⅢ, Ⅳ-C and PLDwere helpful in clinical diagnosis of petients with livercirrhosis and in judgment of developing tendency inpetients with chronic HBV inhetion. Combineddetermination of PCⅢ and LN can elevate the specificity inthe diagnosis of cirrhosis.

关 键 词：肝炎.乙型 肝硬化 肝肿瘤 胶原/血液 层粘蛋白/血液 脯氨酸肽酶/血液 

分 类 号：R735.7[医药卫生—肿瘤]