原发性肝细胞癌单介入治疗与双重介入治疗比较  

SINGLE AND DOUBLE INTERVENTIONAL THERAPY FORPRIMARY HEPATOCELLULAR CARCINOMA

作　　者：吴沛宏[1,2,3,4] 李立[1,2,3,4] 张益民[1,2,3,4] 张福君 郑列[1,2,3,4] 何长青[1,2,3,4] 庞宣文[1,2,3,4] 谢琦 

机构地区：[1]中山医科大学肿瘤中心 [2]河北省邯郸市医学专科学校 [3]中国人民解放军总院 [4]广州市第一人民医院

出　　处：《中山大学学报（医学科学版）》1998年第S1期63-65,共3页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：目的：比较原发性肝细胞癌经皮导管肝动脉栓塞化疗（ＴＡＣＥ）与ＴＡＣＥ联合ＣＴ导向下碘油乙醇注射消融（ＣＴ－ＬＰＥＩ）的疗效。方法：原发性肝细胞癌８６例，分为单介入治疗组，经导管肝动脉栓塞化疗（ＴＡＣＥ）４２例；双重介入治疗组４４例，ＴＡＣＥ联合ＣＴ导向下碘油乙醇消融。结果：ＴＡＣＥ组１、２、３年的生存率分别为６９％，４２％和２０％，组织学检查，仅２０％的病变完全坏死；ＴＡＣＥ联合ＣＴ－ＬＰＥＩ组，１、２、３年生存率分别达１００％、８７％和６７％，组织学检查８５％的病变完全坏死。２组间１、２、３年生存率和肿瘤的完全坏死率均有显著差异。Objective:To compare the therapeutic effectiveness of transcatheter arterial chemoembolization (TACE) combined with CT guided percutaneous lipiodol-ethanol injection (CT-LPEI) with that of TACE alone.Methods:[WT8.5BZ]The group of single interventional treatment in 42 cases was treated with TACE, the group of double interventional treatment in 44 cases was treated with TACE and CT-LPEI.Results:In Single inter ventional group the 1,2,and 3 year survival rates were 69%,42%,and 20%, respectively. Histologic examination of specimens obtained from hepatectomy showed that TACE caused complete necrosis in only 20%. In contrast, TACE combined with CT-LPEI significantly (P<0.05) increased the 1,2, and 3 year survival rates which were 100%, 87% and 67% respectively. Combination therapy produced complete histologic necrosis in 85%, it was significantly (P<0.05) higher than that of TACE alone. Conclusions[WT8.5BZ]:The therapeutic effect of TACE combined with CT-LPEI is much better than that of TACE alone.

关 键 词：肝肿瘤/放射治疗法 放射学.介入性 栓塞.治疗性 醇.乙/治疗应用 

分 类 号：R730.55[医药卫生—肿瘤] R735.7[医药卫生—临床医学]