细胞粘附分子CD15在胆囊癌组织中的表达  

Expression of the cell adhesion molecule CD15 in the gallbladder carcinoma

作　　者：谷化平[1] 胡海霞[1] 尚培中[1] 

机构地区：[1]解放军251医院,张家口075000

出　　处：《中国肿瘤临床与康复》1998年第6期19-20,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的与方法应用免疫组化SP法检测了细胞粘附分子CD15在45例原发性胆囊腺癌、17例胆囊腺瘤和10例慢性胆囊炎组织中的表达。结果发现CD15在胆囊癌中的阳性率为对.1％,显著高于胆囊良性病变（P＜0.01）。CD15的表达与胆囊癌的分化程度和转移状况相关。结果提示,CD15可能在脸羹癌的发生发展、分化、增殖和转移能力上起着重要作用。检测CD15的表达状况,可作为判断胆囊癌的分化程度、转移和预测预后的重要参考指标。Purpose and Method The expression of the cell adhesion molecule CD15 was immunohistochemically investigated in 45 primary gallbladder carcinoma and 17 adenoma of the gallbladder and 10 chromic cholecystitis. Results The percentage of positive cases in carcinoma of the gallbladder (71. 1 % ) was significantly higher than that in benign tissues (P＜0.01 ). The expression of CD15 was found to be significantly correlated with differentiation and metastasis in the gallbladder carcinoma. Conclusion These results suggest that CD15 expression could be involved in aggresiveness of the gallbladder cancer and might be a good marker for assessing the differental grade and metastatic proclivity and prognosis in patients with the gallbladder carcinoma.

关 键 词：胆囊肿瘤 细胞粘附分子 CD15 肿瘤转移 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]