Preparation of Enantiomerically Pure 1,1'-Bi-2-naphthols from 85% Cinchonine and 1,1'-Bi-2-naphtholboric Anhydride  

作　　者：Xiong, Ying  Shan, Zixing  Cheng, Fuyong  Huang, Shiwen  Zhao, Dejie 

出　　处：《Wuhan University Journal of Natural Sciences》1998年第3期91-93,共3页武汉大学学报（自然科学英文版）

摘　　要：A possibility of preparation of enantiomerically pure 1,1' bi 2 naphthols using an impure cinchonine has been examined. The solid and the mother liquor formed from the reaction of 1,1' bi 2 naphtholboric anhydride and 85 % cinchonine in toluene could give optically pure (S) ( ) and (R) (+) 1,1' bi 2 naphthol after acidification and kinetic crystallization, the overall yields were 40 % and 28 %, respectively.A possibility of preparation of enantiomerically pure 1,1' bi 2 naphthols using an impure cinchonine has been examined. The solid and the mother liquor formed from the reaction of 1,1' bi 2 naphtholboric anhydride and 85 % cinchonine in toluene could give optically pure (S) ( ) and (R) (+) 1,1' bi 2 naphthol after acidification and kinetic crystallization, the overall yields were 40 % and 28 %, respectively.

关 键 词：bi  2  naphthol ENANTIOMER PREPARATION CINCHONINE resolution 

分 类 号：TQ463[化学工程—制药化工]