盐酸戊乙奎宁对敌敌畏致脑电改变的对抗作用  

EFFECTS OF PENEQUININE HYDROCHLORIDE ON EEG CHANGES INDUCED BY DICHLORVOS IN RATS

作　　者：杨新波[1] 黄正明[1] 曹文斌[1] 王忠孝[2] 马秀英[3] 

机构地区：[1]解放军北京医学高等专科学校药理教研室,北京100071 [2]解放军总医院临床药理室,北京100853 [3]军事医学科学院毒物药物研究所,北京100850

出　　处：《解放军药学学报》1997年第4期196-199,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：敌敌畏15mg·kg^(-1),可致大鼠脑电出现去同步化,少数出现癫痫波,大部分动物死亡。剂量增大至20mg·kg^(-1),癫痫波的发生数未见增加,表明敌敌畏引起的改变以去同步化为主。预防给药中盐酸戊 乙奎宁2mg·kg^(-1),可完全对抗敌敌畏所致的脑电图变化;ip阿托品2mg·kg^(-1),仅部分对抗。当剂量增大至4mg·kg^(-1)时,虽然动物存活数略有增加,但去同步化及癫痫波的发生数也增加。提示盐酸戊乙奎宁对敌敌畏中枢毒性有较好的对抗作用。Dichlorvos (DDVP) 15mg · kg^(-1), ip, produced desynchronization activity in EEG in all rats and epileptiform activity only in a few animals, most of them died. Pretreated with Penequinine Hydrochloride (PCHE) 2mg·kg^(-1), ip, the above EEG changes could be fully antagonized.Atropine (Atr) only antagonized EEG changes in part of animals. When the dose was increased to 4mg· kg ^(-1), the number of rats developed epileptiform was even increased. The results indicated that the characteristic of EEG following DDVP poisoning is desynchronized activity, which is antagonzed completely by PCHE and partly by Atr.

关 键 词：敌敌畏 盐酸戊乙奎宁 阿托品 脑电图 

分 类 号：R96[医药卫生—药理学]