直肠癌术前放疗前瞻性研究  

PRE-OPERATIVE RADIOTHERAPY FOR RECTAL CANCER:A PREOSPECTIVE RANDOMIZED TRIAL ON 225 CASES

作　　者：孙光绮[1] 王瑞芝[1] 高永君[1] 崔守仁[1] 

机构地区：[1]哈尔滨医科大学附属第三医院,150040

出　　处：《中华放射肿瘤学杂志》1995年第4期29-31,67,共4页Chinese Journal of Radiation Oncology

摘　　要：1978年 10月～ 1983年 12月治疗 2 2 5例直肠癌病人 ,随机分为术前放疗组 115例 ,单术组 110例。照射剂量 30～ 4 5 Gy/ 3～ 4 .5周 ,照射后 2～ 4周做根治或姑息性切除。结果术前放疗组淋巴结转移率及局部复发率为 2 0 .6 %、2 7.8% ,低于单术组的 32 .7%、4 1.8% (P<0 .0 5 )。术前放疗组 5 ,7年生存率分别为 5 7.4 %、4 5 .2 % ,高于单术组的 4 2 .7% ,31.8% (P<0 .0 5 )。术前放疗组 C期 5年生存 5 4 .7% ,高于单术组的 2 8.6 % (P<0 .0 5 )。术前放疗可改变肿瘤局部结构 ,提高 5 ,7年生存率 ,应用于中晚期病例更有意义。From October 1978 through 1983, 225 rectal cancer patients were randomized into R+S group (115 patients) and S only group (110 patients). The radiation dose of pre-operative radiotherapy was 30～45Gy/3～4.5 wks. Radical or palliative resection was done after a rest of 2～4 weeks. The lymphatic metastasis and local recurrence rates of the R+S group (20.6% and 27.8%) were lower than those of the S only group(32.7% and 41.8%)(P<0.05). The 5- and 7-year survival rates of the R+S group(57.4% and 45.2%) were higher than those of the S only group(42.7% and 31.8%) (P<0.05). For stage C lesions, the 5-year survival of R+S group(54.7%) was much higher than that of S only group(28.6%)(P<0.05). The authors believe that pre-operative radiotherapy is able to improve the prognosis of rectal cancer, especially for the advanced lesions.

关 键 词：直肠癌 术前放疗 

分 类 号：R735.37[医药卫生—肿瘤]