THE　BLOCKING　EFFECTS　OF　GLYCYRRHIZE　URALENSIS　AND　CHELIDONIUM　MAJUS　ON　MUTAGENESIS　INDUCED　BY　AFLATOXIN　B1  

作　　者：史桂芝 纪新华 梁益新 陈小琦 

出　　处：《Chinese Journal of Cancer Research》1994年第2期126-130,共5页中国癌症研究（英文版）

摘　　要：Glycyrrhiza Uralensis(GU) and Chelidoniuni Majus (CM) (25,50,100, 200 mg/plate) have obvious blocking effects on Salmonella Typhimurium strains (TA97,TA98,TA100, TA102) mutagenesis induced by aflatoxim B1 (AFB1). The blocking rates of GU and CM are more dependent on the doses. A compound of GU and CM, called Wei Lingsu (WLS), could impede chromosomol aperrations and sister chromatid exchanges (SCE) of human peripheral lymphocyte induced by AFB1, at the concentrations of 150 mg/ml, the blocking rates are 52. 94% 88. 24% and 15. 50% 38. 23% saperatly. WLS could also impede the inhibition of AFB1 to lymphocyte mitosis.Glycyrrhiza Uralensis(GU) and Chelidoniuni Majus (CM) (25,50,100, 200 mg/plate) have obvious blocking effects on Salmonella Typhimurium strains (TA97,TA98,TA100, TA102) mutagenesis induced by aflatoxim B1 (AFB1). The blocking rates of GU and CM are more dependent on the doses. A compound of GU and CM, called Wei Lingsu (WLS), could impede chromosomol aperrations and sister chromatid exchanges (SCE) of human peripheral lymphocyte induced by AFB1, at the concentrations of 150 mg/ml, the blocking rates are 52. 94% 88. 24% and 15. 50% 38. 23% saperatly. WLS could also impede the inhibition of AFB1 to lymphocyte mitosis.

关 键 词：Glycyrrhiza Uralensis(GU) Chelidonnium Majus(CM) Blockinhg effects  Mutagenesis. 

分 类 号：R730.2[医药卫生—肿瘤]