THE SIGNIFICANCE OF IMMUNO-STAIN WITH HLC_3-AB IN CEREBRAL METASTATIC TUMOR  

作　　者：张福林 胡金秀 王善祥 刘尚廉 张骏 

出　　处：《Chinese Journal of Cancer Research》1994年第3期211-215,共5页中国癌症研究（英文版）

摘　　要：By using the immunohistochemical technique(ABCmethod), 186 cases of cerebral metastatic tumors labeled with McAb against human lung carcinoma are reported. They were divided into two groups: primary site determined group and undetermined group. In determined group(59 cases) . 33/36 cases( 91. 6 % ) of lung carcinomas showed HLC3 positive reactions, but among 23 cases of other cancers, only two cases showed weak positive reactions.This result indicated that the HLC3 have strong specific reaction to the lung carcinomas. In undetermined group( 127 cases), 68 cases of metastatic tumors reacted to HLC3 positively. In all 186 cases of cerebral metastatic tumor, there were 101 cases( 53. 5%) showing positive reaction to HLC3- AB. Among 125 cases of cerebral metastatic adenocarcinoma, 76 cases( 61 %) showed positive reactions with HLC3-AB. The result in this paper proved that the lung carcinoma was the important primary site of the cerebral metastatic tumor operated neurosurggically. The specifity of McAb HLC3- AB, the incidance of the cerebral metastatic lung carcinoma and its metastatic course were discaussed.By using the immunohistochemical technique(ABCmethod), 186 cases of cerebral metastatic tumors labeled with McAb against human lung carcinoma are reported. They were divided into two groups: primary site determined group and undetermined group. In determined group(59 cases) . 33/36 cases( 91. 6 % ) of lung carcinomas showed HLC3 positive reactions, but among 23 cases of other cancers, only two cases showed weak positive reactions.This result indicated that the HLC3 have strong specific reaction to the lung carcinomas. In undetermined group( 127 cases), 68 cases of metastatic tumors reacted to HLC3 positively. In all 186 cases of cerebral metastatic tumor, there were 101 cases( 53. 5%) showing positive reaction to HLC3- AB. Among 125 cases of cerebral metastatic adenocarcinoma, 76 cases( 61 %) showed positive reactions with HLC3-AB. The result in this paper proved that the lung carcinoma was the important primary site of the cerebral metastatic tumor operated neurosurggically. The specifity of McAb HLC3- AB, the incidance of the cerebral metastatic lung carcinoma and its metastatic course were discaussed.

关 键 词：Brain tumor Cerebral metastasis HLC3- AB. Lung carcinoma. Immunohistochemical technique. 

分 类 号：R739.41[医药卫生—肿瘤]