Studies　on　the　mechanism　of　insulin　resistance　of　adipose　tissue　after　scalding　in　rats  

作　　者：许霖水 吴喜贵 

出　　处：《Journal of Medical Colleges of PLA(China)》1994年第2期135-137,共3页中国人民解放军军医大学学报（英文版）

摘　　要：The binding activity of insulin receptors, the insulin effects on low Km-cAMP phosphodiesterase (cAMP-PDE) and the level of free fatty acid and cAMP in the adipose tissue were observed on the 4th day after the rats were inflicted with 30% TBSA full thickness scalding. It was found that the maximal binding capacity of the insulin receptors was greatly reduced, and the sensitivity of low Km-cAMP-PDE to insulin decreased. Although the maximal responsiveness was not apparently altered, the dose-response curve was shifted to the right and ED50 increased. The level of free fatty acid and cAMP was not significantly changed in the adipose tissue,These findings indicate that the antilipolytic effect of superphysiological dosage of insulin does not change after scalding.Ｓｔｕｄｉｅｓｏｎｔｈｅｍｅｃｈａｎｉｓｍｏｆｉｎｓｕｌｉｎｒｅｓｉｓｔａｎｃｅｏｆａｄｉｐｏｓｅｔｉｓｓｕｅａｆｔｅｒｓｃａｌｄｉｎｇｉｎｒａｔｓ￥ＸｕＬｉｎｓｈｕｉ（许霖水），ＷｕＸｉｇｕｉ（吴喜贵）．（Ｄｅｐａｒｔｍｅｎｔｏｆｂｉｏｃｈｅｍｉｓ...

关 键 词：BURNS INSULIN RESISTANCE INSULIN receptor phosphodiesterase. 

分 类 号：R335.6[医药卫生—人体生理学]