乙型肝炎病毒母婴传播阻断的研究  

A Study on the Interruption of Vertical Transmission of HBV

作　　者：刘逢举[1] 郑邦德[1] 徐小元 安平[1] 王华信[1] 杨晶[1] 张国华 宋晓玲 郭振华[1] 肖平 

机构地区：[1]兰州医学院传染病研究室

出　　处：《兰州大学学报（医学版）》1989年第4期214-217,共4页Journal of Lanzhou University（Medical Sciences）

摘　　要：本文对276例HBsAg阳性母亲及其新生儿血清进行HBV标志检测。母血HBeAg和PHSA-R阳性率分别为48.9％和52.9％。婴儿脐血HBsAg阳性率9.8％(27/276)。对276例新生儿按0、1、3、6月程序,每次肌肉注射乙肝疫苗10μg进行阻断研究。生后9月龄,脐血HBsAg阴性组212例抗-HBs阳转率86.8％,随访24月龄时抗-HBs阳性率91.4％。脐血HBsAg阳性组27例抗HBs阳转率51.9％,9例HBsAg持续阳性。母血HBV标志和婴儿性别对疫苗阻断效果无明显影响。抗-HBs阳转组婴儿血清PHSA-R和HBV-DNA检测均阴性。表明单独使用乙肝疫苗阻断乙肝病毒母婴传播可取得满意效果。Serological HBV markers were detected in 276 cases of HBV carrier mothers and their infants. Positive rate of HBeAg and PHSA-R were 48.9％ and 52.9％ respectively. Positive rate of HBsAg in umbilical cord blood was 9.8％ ( 27/276 ). We injected HBV vaccine to 276 infants born from mothers with HBV infection with dosage of 10 HBsAg protion at 0、1、3、6 month of age respectively. The positive rate of HBsAb was 86.8％ at 9 month of age in which 51.9％ in 27 infants with HBsAg positive respectively. At 24 month of age positive rate of HBsAb was 91.4％. Those results were similar with reported effects of immunization program with both HBV vaccine and HBIG. In addition, HBV-DNA and PHSA-R was not detected in all HBs Ab positive infants. Positive rate of Anti-HBs in 21 cases with HBsAg positive in umbilical cord blood was 51.9％. HBsAg was constants in 9 cases. HBV markers of mother and sex of infant did not significance on effect of vaccine immunization. The result indicates that using HBV Vaccine only are the good method.

关 键 词：乙型肝炎病毒 母婴传播 乙肝疫苗 

分 类 号：R[医药卫生]