怀地黄对中枢神经系统的抑制效应  

DEPRESSANT EFFECT OF REHMANNIA GLUTINOSA ON CENTROL NERVOUS SYSTEM

作　　者：吴尚魁[1] 刘鹤香[1] 刘春霞[1] 肖振民[1] 

机构地区：[1]新乡医学院基础医学部药理教研室

出　　处：《新乡医学院学报》1989年第1期12-14,共3页Journal of Xinxiang Medical University

摘　　要：本实验观察了怀地黄对小鼠中枢神经系统的影响,对其作用机理作了初步探讨,结果表明,怀地黄水提取液可抑制小鼠的自主活动,可加强阈下催眠剂量戊巴比妥钠和硫喷妥钠的催眠作用,同时可对抗安钠咖的兴奋作用,但不能对抗硝酸士的宁和戊四氮所致的惊厥作用,说明怀地黄有明显镇静作用,作用部位可能在大脑皮层。The pharmacological effect of rehmannia glutinosa on the centrol nervous system was investigated. The results show that the rehmannia glutinosa can inhibit the automatic activity of the mouse, strengthen the depressant effect of pentobarbital sodium and thiopentone sodium to the centrollnervous system, antagonize the centrol stimulation of caffein to mouse. But it can not antagonize the convulsion of cardiazol and strychnine. The experiment shows that the rehmannia glutinosa possesses a sedative effect.

关 键 词：生地 鼠 镇静实验 

分 类 号：R[医药卫生]