肺癌组织中MTA1,HDAC1,HIF-1α蛋白表达的相关性研究  

Correlations between protein expression of MTA1,HDAC1 and HIF-1α in lung cancers

作　　者：朱晓霞[1] 郭煜[2] 陈龙华[1] 丁彦青[3] 

机构地区：[1]南方医科大学南方医院放疗科,广东广州510515 [2]南方医科大学南方医院内分泌科,广东广州510515 [3]南方医科大学南方医院病理科,广东广州510515

出　　处：《第四军医大学学报》2009年第7期664-666,共3页Journal of the Fourth Military Medical University

基　　金：国家"863"计划项目(2006AA022478);国家自然科学基金(30772530)

摘　　要：目的:探讨肺癌组织中转移相关蛋白1(MTA1),组蛋白去乙酰化酶1(HDAC1),低氧诱导因子(HIF-1α)蛋白表达三者之间的相互关系.方法:采用免疫组织化学染色方法检测59例肺癌组织中MTA1,HDAC1及HIF-1α的表达情况,并分析三者之间的相关性.结果:MTA1蛋白的表达与HIF-1α的表达呈显著正相关(r=0.418,P<0.05),且HIF-1α表达与MTA1/HDAC1染色水平明显相关.结论:HIF-1α,MTA1/HDAC1复合物在人类肺癌的发展中有重要意义.HIF-1α和HDAC1/MTA1可能是针对这种致死性疾病而发展的新治疗方式的一个有前途的靶点.AIM： To explore the correlations between protein expression of MTA1, HDAC1 and HIF-1α in lung cancers. METHODS： MTA1, HDAC1 and HIF-1α expressions were detected by immunohistochemistry in 59 lung cancer patients. The correlations between the expression of MTA1, HDAC1 and HIF- 1α were analyzed. RESULTS： There was a positive association between the expression of MTA1 and HIF-1α（ r = 0. 418, P 〈 0.05）. HIF-1α expression was correlated markedly with the MTA1/HDAC1 staining level. CONCLUSION： HIF-1α and MTA1/HDAC1 complex are of some significance in the development of human lung cancers. HIF-1α and HDAC1/MTA1 may be promising targets for novel therapeutic approaches to human lung cancers.

关 键 词：肺肿瘤 转移相关蛋白1 低氧诱导因子 免疫组织化学染色 

分 类 号：R734.2[医药卫生—肿瘤]