离体S-8711放射增敏作用的研究  

IN VITRO RADIOSENSITIZATION EXPERIMENT OF S-8711

作　　者：糜福顺[1] 李政[1] 沈瑜[1] 胡璧[2] 王荣先[2] 李美佳[2] 施培基[2] 

机构地区：[1]中国医学科学院肿瘤医院 [2]中国医学科学院放射医学研究所

出　　处：《中华放射肿瘤学杂志》1989年第2期35-37,共3页Chinese Journal of Radiation Oncology

基　　金：国家"七五"攻关课题

摘　　要：尽管Misonidazol在临床应用上受到神经毒性的限制,但是,寻找低毒高效乏氧细胞放射增敏剂依然是肿瘤放射生物学者及药物学者感兴趣的研究课题。The radiosensitizing effect of 6-nitroindazole compound (S-8711)on Hela-S3 cell line was investigated in vitro using cell colony forming assay. At concentration of 2 mM, sensitizing. enhancement radio (SER) of S-8711 calculated at Do and Dq were 1.36 and 2.11 as compared with the SER of MISO at the same concentration,1.38 and 1.85. When the concentration was raised to 6 mM, S-8711 SER at Do and Dq (1.41 and 2.0) was less than those of MISO (1.79 and 2.24). Some radioprotection of this compound on oxic Hela-S3 cells was also observed.

关 键 词：放射增敏作用 S-8711 放射增敏剂 乏氧细胞 放射生物学 神经毒性 乏氧状态 增敏比 细胞存活曲线 临床应用 

分 类 号：R73[医药卫生—肿瘤]