小剂量肝素治疗冠心病心绞痛疗效观察  

Use of Heparin in small dosage in treatment of angina pectoris

作　　者：林运昌[1] 孙静平[1] 李次芬[2] 李瑞友[2] 

机构地区：[1]中国人民解放军军医进修学院保健办六科 [2]中国人民解放军军医进修学院血液病室

出　　处：《解放军医学院学报》1989年第3期196-198,共3页Academic Journal of Chinese PLA Medical School

摘　　要：本文报告20例应用小剂量肝素治疗冠心病心绞痛的临床效果。结果表明,肝素的有效剂量为100mg/日,用药后65％的患者心绞痛症状完全消失,心电图相应改善,血小板聚集力(PAgT)及粘附力(PAdT)测定明显减低。对血沉、血小板计数、凝血时间及凝血酶元时间、活动度的影响不明显,可能与肝素用量小有关。治疗过程中,无一例发生出血并发症。为防止停药后的反跳现象,以逐渐减量为宜。通过观察证明,小剂量肝素治疗冠心病心绞痛,用药安全,具有一定疗效。This paper reported the effect of Heparin in treating 20 cases of angina pectoris. The result showed that the effects of Heparin were evident on relieving pectoris, reducing frequency of attacks, improving electrocardiogram and inhibiting PAgT and PAdT etc, and that the effects of treatment were better when the heparin was given in dosage of 100 mg per day than in dosage of 50 mg and 25 mg per day, by intramuscular injection.

关 键 词：肝素 心绞痛 血小板凝 血小板粘附 

分 类 号：R82[医药卫生—临床医学]