青少年与中老年甲状腺功能亢进患者^131I治疗的疗效分析  

Therapeutic effects of ^131I therapy on hyperthyroidism in adolescents and adults： a comparative study

作　　者：董建军[1] 邢海燕[2] 付春莉[1] 侯新国[1] 赵家军[2] 廖琳[2] 

机构地区：[1]山东大学齐鲁医院内分泌科,济南250012 [2]山东大学附属省立医院内分泌科

出　　处：《中华医学杂志》2009年第14期973-976,共4页National Medical Journal of China

摘　　要：目的通过比较分析^131I对青少年和中老年甲状腺功能亢进（甲亢）的临床疗效，探讨^131I治疗青少年甲亢的可行性。方法940例在山东大学齐鲁医院及山东省立医院进行^131I治疗的甲亢患者入选，按年龄分为3组，青少年组（〈25岁）：106例患者，中年组（25-60岁）：768例，老年组（〉60岁）：66例。随访2年，分析3组的疗效差异。结果青少年组痊愈46例（43．4％），好转34例（32．1％），甲减24例（22．6％），无效2例（1．9％），有效率为98．1％；中年组痊愈346例（45。1％），好转260例（33．9％），甲减140例（18．2％），无效22例（2．9％），有效率为97．1％；老年组痊愈28例（42．4％），好转24例（36．4％），甲减10例（15．2％），无效4例（6．1％），有效率为93．9％。X^2检验显示各年龄组间痊愈率、好转率、甲减率、无效率之间差异均无统计学意义（均P〉0．05）。结论青少年甲亢患者接受^131I治疗效果与中老年患者无差异，^131I治疗青少年甲亢是有效、可行的。Objective To investigate the efficacy and safety of ^131I therapy on hyperthyroidism in adolescents, middle-aged people, and the elderly. Methods 940 patients with hyperthyroidism, 106 aged 〈 25 （Group A, group of young people）, 768 aged 25 - 60 （ Group B, middle-aged group）, and 66 aged 〉60 （Group C, group of the elderly） , underwent ^131I therapy and were followed up for 2 years to evaluate the efficacy and safety. Results Forty-six patients in group A （43.4%） became euthyroid, 34 （ 32.1% ） turned better, 24 （22.6%） suffered from hypothyroidism, and 2 （1.9%） remained un-changed, with a general effective rate of 98.11% （104/106）. 346 patients （45. 1% ）in Group B became euthyroid, 260 （33.9%） tumed better, 140 （18.2%）suffered from hypothyroidism, and 22 （2.9%） remained un- changed, with a general effective rate of 97.14% （746/768）. And 28 patients（42.4% ）in Group C became euthyroid, 24 （ 36.4 % ） turned better, 10 （ 15.15 % ） suffered from hypothyroidism, and 4 （ 6.1% ） remained unchanged, with a general effective rate of 93.93% （62/66）. There were not significant differences in the recovery rate, improvement rate, hypothyroidism rat, and ineffective rate among the 3 groups （all P 〉 0.05）. Conclusion There are no significant differences in the efficacy and safety of ^131I therapy in hyperthyroidism on the patients of different ages, including adolescent, adult and elder persons. ^131I therapy is safe and effective for adolescents.

关 键 词：甲状腺功能亢进症 碘放射性同位素 青少年 

分 类 号：R686[医药卫生—骨科学]