国产干扰素(赛诺金)联合CHOPP方案治疗皮肤T细胞淋巴瘤的疗效观察  

The Clinical Study of Treating Skin T-lymphoma with Domestic Interferon(Sainuojin) and CHOPP-regimen

作　　者：官成浓[1] 李姝君[1] 蔡良真[1] 梁启廉[1] 

机构地区：[1]广东医学院附属医院肿瘤内科,湛江524001

出　　处：《医学研究杂志》2009年第4期67-68,共2页Journal of Medical Research

摘　　要：目的探讨低剂量国产干扰素(赛诺金)联合CHOPP方案治疗皮肤T细胞淋巴瘤(CTCL)的疗效及不良反应。方法1996年6月～2008年6月,采用低剂量国产干扰素(赛诺金)联合CHOPP方案治疗46例皮肤T细胞淋巴瘤患者,全部病例均接受至少4周期化疗。赛诺金300万U,im,qod;CTX600mg/m2,iv,d1;ADM50mg/m2,iv,d1;VCR1.4mg/m2,iv,d1;泼尼松90mg/d,顿服,d1～5;PYM8mg/d,im,d1、3、5,3周重复。化疗同时,皮损处涂抹盐酸氮芥溶液,每日1次。结果CR23例,PR16例,NC7例。有效率84.78%。生存时间最长11.6年,平均生存时间8.9±0.56年;主要不良反应为骨髓抑制和一次性发热。结论低剂量国产干扰素(赛诺金)联合CHOPP方案治疗皮肤T细胞淋巴瘤疗效肯定,毒不良反应小,值得临床推广应用。Objective To discuss the curative effects and side - effects of combining low - dose domestic interferon（sainuojin） with CHOPP - regimen in treating skin T - lymphoma. Method During the period June 1996 to June 2008,46 cases patient with skin T - lymphoma were treated by low -dose domestic interferon（sainuojin） and CHOPP - regimen, and all patient were received four cycle chemo- therapy at least. And the usage was as follows： Sainuojin 3×10^6U/d, im, d1-21; CTX 600mg/m^2 , iv, d1; ADM 50mg/m^2 , iv, dI ; VCR 1.4mg/m^2 , iv, d1; Predinisone 90 mg/d, PO, d1-5 ; PYM 8mg/d, im, d1、3、5, and every 3 weeks repeat. At the same time, the place of skin lesion was daubed with hydrochloric acid nitrogen mustard once everyday. Results CR 23 cases,PR 16 cases, NC 7 cases. The effective rate was 84.78%. The maximum time of survivorship was 11.6 years ; the average survivorship time was 8.9 ±0. 56 years ;and the mostly side - effects were arrest of bone marrow and fever. Conclusion The curative effects of combining low - dose domestic interferon（sainuojin） with CHOPP - regimen in treating skin T - lymphoma were confirmed,and the side - effects were small. It is good for clinical popularization and application.

关 键 词：皮肤T细胞淋巴瘤 CHOPP方案 干扰素 赛诺金 

分 类 号：R739.5[医药卫生—肿瘤] R521[医药卫生—临床医学]