吸入高低氧联合后程加速超分割放疗对食管癌的疗效探讨  

The efficacy of inspiring carbogen and low concentration oxygen combined with late course accelerated hyperfraction radiotherapy on esophageal carcinoma

作　　者：孙衍伟[1] 周嘉云[1] 安永恒[2] 

机构地区：[1]日照市人民医院肿瘤科,山东省日照276800 [2]青岛大学附属医院肿瘤科

出　　处：《中国基层医药》2009年第3期402-404,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 评价吸入高低氧联合后程加速超分割放疗对食管癌的临床疗效。方法74例患者随机分为试验组和对照组。试验组常规分割放疗DT38—40Gy后改为DT1．3—1．4Gy／次，每天2次，间隔时间〉6h，中位总剂量DT64．2Gy，放疗过程中先后吸入高低浓度氧。对照组常规分割放疗1．8-2．0Gy／次，每周5次，中位总剂量65．6Gy。结果获得病例71例。放疗DT30Gy时，试验组完全缓解率（CRR）为31％，对照组CRR为19％（P〉0．05）；放疗结束时，试验组CRR为57％，对照组CRR为31％（P〈0．05）；放疗结束1个月后，试验组CRR为71％，对照组CRR为33％（P〈0．01）；放疗后6个月，试验组CRR为74％，对照组CRR为36％（P〈0．01）；试验组6个月局部控制率为91％，对照组为72％（P〈0．05）。两组的毒副反应差异无统计学意义。结论吸入高低氧联合后程加速超分割放疗明显提高了Ⅰ-Ⅲ期食管癌的近期疗效及局部控制率，毒副反应可耐受。Objective To evaluate the efficacy of inspiring carbogen and low concentration oxygen combined with late course accelerated hyperfraction radiotherapy on esophageal carcinoma. Methods 74 patients with esophageal carcinoma were randomly divided into two groups：the trial group and the control group, which consisted of 37 patients respectively. 6MV X-ray was employed in the two groups. The schedule of the trial group was as following：conventional radiotherapy of 1.8 - 2.0Gy per day was employed during the first phase to a total dose of 38 - 40Gy, followed by late course accelerated hyperfraction radiotherapy （ twice fractions per day, interval between two fractions more than 6 hours, 1.3 - 1.4Gy per fraction ,middle total, dose of 64.2Gy）. Carbogen and low coneentraction oxygen was inspired during the course of radiation. Results 71 patients were enrolled. At the end of radiation at a total dose of 38-40Gy,eomplete remission rate（CRR） in the trial group was 31% ,whereas that in the control group was 19% （ P 〉 0.05 ）, when the whole radiotherapy was finished, the CRR was 57 % and 31% （ P 〈 0.05 ） respectively, and one month after radiotherapy,the CRR was 71% and 33% respectively （ P 〈 0.01 ）. Six months after radiotherapy, the CRR was 74% and 36% respectively（ P 〈 0.01 ）. The local control rate of six months was 91% and 72% respectively in the two groups （ P 〈 0. 05 ）. Condusions Inspiring carbogen and low concentration oxygen combined with late course accelerated hyperfraction radiotherapy may significantly improve short-term efficacy and local control rate in esophageal carcinoma patients in Ⅰ -Ⅲ stage. Furthermore, its side effects can be tolerated, and its elongating life time of patients may be prognostic.

关 键 词：食管肿瘤 氧吸入疗法 放射疗法 

分 类 号：R735[医药卫生—肿瘤]