MB 麻风病人血清中的 TNF_α和 SIL-2R  

TNF—α and SIL—2R in the Sera of MB Leprosy Patients

作　　者：高锦程[1] 郑碧忠 金刚石 方海林[4] 李敏伟[4] 

机构地区：[1]浙江医科大学附属邵逸夫医院皮肤科 [2]浙江兰溪市皮肤病防治站 [3]浙江桐乡市皮肤病防治院 [4]浙江医科大学传染病研究所分子免疫室

出　　处：《中国麻风杂志》1998年第1期10-12,共3页

摘　　要：为进一步了解 MB 麻风的细胞因子水平,探讨在麻风抗感染免疫和发病中,细胞因子与麻风特异性细胞免疫缺陷之间可能存在的关联,对浙江兰溪和桐乡地区的 MB 病人及其治愈者和当地正常人的血清 SIL—2R 和 TNF_α进行了检测。结果发现 MB 病人血清中的 SIL—2R 和 TNF_α水平升高,并呈正相关(R=0.667,t=2.536,P<0.025),且均高于健康对照组和 MB 治愈者(P<0.01～0.001),其中以 LL 病人的 SIL—2R 和 MB 复发者的 TNF_α水平最高,而治愈者的均明显低于对照组(P<0.001);提示 MB 病人中有细胞因子—SIL—2R 及 TNF_α的调节异常和免疫功能受抑制;高水平的 TNF_α并未对病人提供保护作用;血清 SIL—2R 和 TNF_α水平与 MB 病人的病情严重程度和复发有明显关系,对判断麻风病人的预后可能有一定价值。In Lanxi and Tongxiang,Zhejiang,SIL—2R and TNF—α in the sera of 10 MDT—treated cases and 18 persons cured of MB leprosy were tested,with 19 local health resi- dents as controls.The results showed that the levels of SIL—2R and TNF—α were raised in the MB cases relevantly (r=0.667,t=2.536,P<0.025),being higher than those of the cures and residents (P<0.001).SIL—2R in LL cases and TNF—α in relapsed MB were the highest, and those in the cures were significantly lower than in the residents (P<0.001).It was indicated that there are abnormalities in regulation of SIL—2R and TNF—α and inhibition of immune function among patients with MB leprosy.

关 键 词：MB麻风病人 麻风 血清 TNFΑ SIL-2R 

分 类 号：R755[医药卫生—皮肤病学与性病学]