Flt-1、PDGFR和MVD的表达与胃癌浸润、转移的相关性  

Relations of Flt-1,PDGFR and MVD expression with invasiveness and metastasis of gastric carcinoma

作　　者：林瑶光[1] 张君红[1] 李佳荃[2] 

机构地区：[1]广西医科大学第一附属医院老年消化内科,广西壮族自治区南宁市530021 [2]广西医科大学医学实验中心,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2009年第6期606-609,共4页World Chinese Journal of Digestology

基　　金：广西科技厅科研基金资助项目;No.0342010-4~~

摘　　要：目的:探讨血管内皮生长因子受体-1(Flt-1)、血小板衍生生长因子受体(PDGFR)和微血管密度(MVD)与胃癌浸润及转移的相关性.方法:选择71例手术切除的胃癌标本为观察组,29例胃癌旁标本及39例正常胃黏膜组织为对照组.应用免疫组织化学方法检测组织中Flt-1、PDGFR蛋白表达及CD34计数.结果:与对照组及癌旁组相比,在胃癌组中的Flt-1、PDGFR阳性率有显著差异(53.5%vs13.8%,12.8%;49.3%vs10.3%,10.2%,均P<0.01).Flt-1、PDGFR的表达与胃癌的浸润、淋巴和远处转移及临床分期密切相关,与肿瘤大小、组织分型无关.MVD在胃癌组与癌旁及对照组之间表达有显著性差异(45.2±15.2vs35.1±5.0,28.6±4.2,均P<0.01).MVD与胃癌浸润深度、淋巴和远处转移及临床分期有显著相关.Flt-1、PDGFR在胃癌中阳性表达以及与微血管密度呈显著相关.Flt-1表达阳性率与PDGFR存在正相关(r=0.5235,P<0.01).结论:胃癌组织中Flt-1、PDGFR的阳性表达和MVD的升高可作为胃癌生长、转移及预后的重要判定指标.他们在胃癌的发生、浸润、转移中可能存在相互诱导、相互协同或叠加作用.AIM： To investigate the correlation of vascular growth factor receptor （Flt-1）, platelet-derived growth factor receptor （PDGFR）, and MVD with invasiveness, and metastasis of gastric cancer.METHODS： Tissue samples from 71gastric carcinoma （GC）, 29 paracarcinoma and 39 normal gastric tissues were examined by using immunohistochemetry for the expression of angiogenic factor receptor and CD34.RESULTS： The positive rates of Flt-1, PDGFR were significantly higher in gastric cancer tissues than in paracarcinoma or than in normal tissues（53.5% vs 13.8%, 12.8%; 49.3% vs 10.3%, 10.2%, all P 〈 0.01）. The high positive expression of the above two receptors had significant correlation with regional invasion, clinical grading, lymph and blood stream metastasis in gastric cancer, but not with size or differentiation degree. The MVD counts of GC were significantly higher than that of patients with paracarcinoma or with normal tissues （45.2 ± 15.2 vs 35.1 ± 5.0, 28.6 ± 4.2, both P 〈 0.01）. The MVD was significantly correlated with regional invasion, clinical grade, lymph and blood stream metastasis in GC. The positive expression rate of Flt-1 was positively correlated with PDGFR （r = 0.5235, P 〈 0.01）.CONCLUSION： The expression of Flt-1, PDGFR and MVD might be significantly correlated with growth, invasion and metastasis of gastric carcinoma. The two receptors together may play coordinative roles in angiogenesis, invasion and metastasis of gastric carcinoma.

关 键 词：胃肿瘤 血管生长因子受体一1 血小板衍 生生长因子受体 微血管密度 

分 类 号：R735.2[医药卫生—肿瘤]