原发性胃肠道淋巴瘤临床病理特征分析14例  

Clinicopathologic features of primary gastrointestinal lymphoma:an analysis of 14 cases

作　　者：高炳霞[1] 王莉[1] 魏南[1] 

机构地区：[1]北京世纪坛医院消化科,北京市100038

出　　处：《世界华人消化杂志》2009年第6期610-613,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨原发性胃肠道淋巴瘤(PGIL)的临床、病理特点、疾病分期、内镜及影像学表现以提高诊治水平.方法:回顾性分析我院1994-01/2008-03经内镜活检或手术病理证实的14例PGIL患者的临床资料.结果:14例PGIL中原发于胃8例,肠道5例,1例为混合部位.临床症状依次为腹痛(92.86%)、消瘦(35.71%)、纳差(28.57%)及腹部包块与贫血(21.42%).病理类型低度恶性淋巴瘤2例(14.29%),高度恶性淋巴瘤12例(其中DLBL2例,伴有MALT成分的DLBL10例).9例患者临床分期为Ⅰ期,3例为ⅡE,2例为Ⅲ期.PIL及混合部位组较PGL组年龄小,二组之间比较差异有显著性(49.00±13.05vs69.12±7.7,P<0.01).结论:PGIL临床症状无特异性,病理类型以高度恶性淋巴瘤常见,PIL及混合部位淋巴瘤发病年龄小且分期晚,值得临床高度重视.AIM： To study the clinicopathologic features of primary gastrointestinal lymphoma （PGIL）.METHODS： Clinical data of 14 cases with pathologically or endoscopically confirmed PGIL at our hospital from January 1994 to March 2008, were retrospectively analyzed.RESULTS： The study comprised 8 patients with primary gastric lymphoma （PGL group）, 5 with primary intestinal lymphoma （PIL group） and 1 with both primary gastric and intestinal lym- phoma （mixed group）. The main clinical symptom was abdominal pain, and others included emaciation, poor appetite, abdominal mass and anaemia. Two patients were classified as lowgrade malignant lymphoma, and 12 patients high-grade lymphoma including 2 diffused large B-cell lymphoma and 10 diffused large B-cell lymphoma plus MALT lymphoma. Nine patients had stage Ⅰ disease, 3 had stageⅡE disease, 2 had stage Ⅲ disease. The average age of patients in the PIL plus mixed group was significantly younger than that in PGL group （49.00 ± 13.05 vs 69.12 ± 7.7, P 〈 0.01）.CONCLUSION： PGIL has no specific clinical symptoms, but deserves highly attention in clinical practice for its late-stage and high-grade lymphoma incidence and early age of onset in PIL and mixed group lymphoma.

关 键 词：原发性胃肠道淋巴瘤 临床病理特征 内镜诊断 治疗 

分 类 号：R735[医药卫生—肿瘤] R735.2[医药卫生—临床医学]