p53基因网络与幽门螺杆菌致胃病关系的研究进展  

Research progress in the relationship between p53 gene network and H pylori-induced gastric diseases

作　　者：齐淑文 谢立群[2] 舒徐[3] 王华[4] 

机构地区：[1]武警江西省总队第一支队卫生队,江西省南昌市330043 [2]中国人民武装警察部队医学院附属医院消化内科,天津市300162 [3]南昌大学第一附属医院消化内科,江西省南昌市330006 [4]南昌大学第一附属医院移植科,江西省南昌市330006

出　　处：《世界华人消化杂志》2009年第7期681-686,共6页World Chinese Journal of Digestology

基　　金：江西省卫生厅课题资助项目;No.051036~~

摘　　要：H pylori与胃黏膜病变关系密切已被公认,H pylori感染可引起胃黏膜细胞增殖与凋亡的失衡,这与其致病致癌密切相关.p53基因这一复杂的网络系统在调控细胞凋亡与增殖的过程中,发挥重要的作用.就p53下游基因网络与H pylori、胃黏膜细胞增殖凋亡之间的关系作一综述.The close relationship between H pylori and gastric mucosa lesions have been commonly recognized. H pylori infection may cause the unbalance of gastric mucosal cell multiplication and apoptosis, which are closely related to the pathogenesis of various gastric diseases such as gastric cancer. The complex network system of p53 gene plays a vital role in the regulation of cell multiplication and apoptosis. This review makes a summary about the relationship among p53 gene downstream network, H pylori infection and gastric mucosal cell multiplication and apoptosis.

关 键 词：pg3 幽门螺杆菌 胃疾病 

分 类 号：R573[医药卫生—消化系统]