颈动脉留置管注射纳络酮治疗缺血性脑卒中的临床研究  

CLINICAL STUDY OF TREATMENY OF ISCHEMIC CEREBRAL STROKE WITH NALOXONE INFUSION THROUGH CAROTID RETAIN TUBE

作　　者：陆寅[1] 马瑞华[1] 焦念宝[1] 张荣银 孟庆莲[1] 

机构地区：[1]泰山医学院第一教学医院神经内科

出　　处：《泰山医学院学报》1998年第1期33-36,共4页Journal of Taishan Medical College

摘　　要：目的为了解决静脉注射纳络酮治疗缺血性脑卒中存在的问题。我们设计了颈动脉留置管注射纳络酮的方法。方法６０例缺血性脑卒中病人随机分为两组，颈动脉留置管注射纳络酮组（３０例）和静脉注射纳络酮组（３０例）。两组均于发病７２小时内开始治疗。结果颈动脉用药组的神经功能恢复程度明显优于静脉用药组（Ｐ＜０．０５）。住院１５天治愈率＋显著进步率：动脉用药组为６６．７％；静脉用药组为２３．３％（Ｐ＜０．０１）。结论颈动脉留置管的注射方法、使药物直接作用于病灶区，一次穿刺可以多次用药，安全可靠、简便易行，可缩短病程，尤其适用于发病早期的患者。Objective To study whether self-designed method of naloxone infusion through carotid retain tube could solve the problems existing in the treatment of ischemic cerebral stroke with naloxone by intravenous injection. Methods 60 patients with ischemic stroke were randomly divided into two groups: group A (naloxone infusion through carotid retain tube, 30 cases) and group B (naloxone infusion by intravenous injection, 30 cases).The treatment was started within 72 hours after the onset of symptoms. Results The recovery of neurological function in group A was significantly superior in degree to group B. After half a month the cure rate and obviouly improved rate in two groups were 66.7% and 23.3%, respectively (P<0.001). Conclusion The method of carotid retain tube can make drugs directly act on focus. One paracentesis can be repeatly used to inject medicine. This method is safe, reliable, simple and practical as well. This treatment may shorten the course of disease, especially to patients at pathogenic stage.

关 键 词：缺血性 脑卒中 纳络酮 颈动脉留置管 治疗 

分 类 号：R743.305[医药卫生—神经病学与精神病学]