幽门螺杆菌iceA1,babA2基因型与临床消化疾病的关系  

Relationship of clinical gastric diseases and the genes,iceA1 and babA2 of Helicobacter pylori isolated

作　　者：陈慧娟[1] 张尤历[1] 唐炜[1] 

机构地区：[1]江苏大学附属医院内科,江苏镇江212001

出　　处：《江苏大学学报（医学版）》2009年第2期173-175,178,共4页Journal of Jiangsu University：Medicine Edition

基　　金：江苏省社会发展基金资助项目(BS2006041)

摘　　要：目的:研究镇江地区幽门螺杆菌(H.Pylori)iceA1,babA2基因型分布及其与临床消化疾病的关系。方法:从70例胃十二指肠疾病患者胃黏膜活检组织中分离培养H.Pylori,PCR扩增检测H.Pylori iceA1,babA2基因型。用χ2检验分析各基因在不同胃十二指肠疾病中的统计学意义。结果:70例菌株的总检出率分别为iceA1 68.6%,babA265.7%。其中iceA1的分布为胃癌12/14(85.7%),慢性胃炎18/30(60%),消化性溃疡18/26(69.2%);而babA2的检出率为胃癌8/14(66.7%),慢性胃炎19/30(63.3%),消化性溃疡19/26(73.1%)。结论:镇江地区分离的H.Pylo-ri的iceA1与babA2基因与胃癌、消化性溃疡、慢性胃炎等疾病类型的发生无显著相关性,但iceA1在胃癌中的检出率高于慢性胃炎与消化性溃疡患者。Objective： To investigate the distribution of iceA1 and babA2 genes of Helicobacter pyloric （ H. Pylori） in Zhenjiang area and the relationship between these genes and clinical gastric diseases. Methods： H. Pylori strains isolated from the patients with different gastric duodenal diseases. The iceA1 and babA2 genotypes were tested by Polymerase Chain Reaction （PCR）. The results were analyzed statistically by Х^2 test. Results： iceA1 and babA2 were detected in 48/70（68.6% ） and 46/70（65.7% ） of total 70 H. pylori strains, iceA was detected in 12/14 （85.7%） of H. pylori gastric carcinoma patients, in 18/30 （60%） of peptic ulcer patients, in 18/26 （69.2%） of chronic gastritis patients, babA2 was detected in 8/ 14（66.7% ） of gastric carcinoma patients, in 19/30（63.3% ） of peptic ulcer patients, in 19/26（73.1% ） of chronic gastritis patients. Conclusion： No association of different clinical diseases with iceA1 and babA2 genotype was detected in patients, while the prevalence of iceA1 isolated from gastric carcinoma patients was higher than that in peptic ulcer and in chronic gastritis patients.

关 键 词：幽门螺杆菌 iceA1基因 babA2基因 上消化道疾病 

分 类 号：R573[医药卫生—消化系统]