原发性食管小细胞癌临床病理分析  

Clinical and pathologic characteristics of primary esophageal small cell carcinoma

作　　者：赵伟鹏[1] 陈锐[2] 段玉忠[1] 陈正堂[1] 

机构地区：[1]第三军医大学新桥医院肿瘤研究所,重庆400037 [2]第三军医大学新桥医院病理科,重庆400037

出　　处：《现代肿瘤医学》2009年第4期660-662,共3页Journal of Modern Oncology

摘　　要：目的:分析原发性食管小细胞癌的临床病理特点,为其综合治疗提供依据。方法:采用回顾性分析方法,对食管癌根治手术的18例食管小细胞癌病例行免疫组化神经元特异烯醇化酶(NSE),突触素(Syn),细胞角蛋白(CK),增殖细胞核抗原(PCNA),嗜铬蛋白A(CgA)等检测。结果:原发性食管小细胞癌18例中,CgA阳性表达率为83.3%(15/18),NSE阳性表达率为83.3%(15/18),Syn阳性表达率为77.8%(14/18),PCNA阳性表达率为72.2%(13/18)、CK阳性表达率为55.5%(10/18)。结论:食管小细胞癌在中国人群中为一种高度恶性肿瘤,预后不良。对神经源性抗原等表达明显增高,早期发现、早期治疗仍是原发性食管小细胞癌的治疗原则。Objective ： To analyse the clinical feature and treatment of primary small cell carcinoma of the esophagus and to indicate comprehensive treatment on primary esophageal small cell carcinoma （PESCC）. Methods ： Eighteen patient records were reviewed including presenting symptoms, disease stage and treatment. Histologic features were observed and immunohistochemical detection of chromogranin A （CgA）, neuron specific enolase （NSE）, synaptophysin（Syn）, proliferating cell nuclear antigen （PCNA）, cytokeratin （CK）, was performed. Results： The percentages of PESC samples with positive immunoreactivity were CgA 83.3%, NSE 83.3%, Syn 77.8% ,PCNA 72.2% , CK 55.5% , respectively. Conclusion： For PESCC Chinese patients have a poor prognosis. Higher proportion of positive labeling of neuron specific antigen in PESCC implicate that they are valuabl in differential diagnosis of the malignancy. Furthermore, early detection and early treatment is very important.

关 键 词：食管小细胞癌 预后 免疫组化 

分 类 号：R735.1[医药卫生—肿瘤]