断流术对肝硬化门脉高压大鼠胃粘膜影响的实验研究  

EXPERIMENTAL STUDY ON PORTAL HYPERTENSIVE GASTRIC MUCOSA AFTER PORTOAGYOUS DISCONNECTION IN RATS

作　　者：周东风[1,2] 汤红岩[1,2] 梁桂华 范连杰[1,2] 李兆亭 王占民[1,2] 

机构地区：[1]济宁医学院附属医院 [2]山东医科大学附属医院

出　　处：《济宁医学院学报》1998年第1期11-14,共4页Journal of Jining Medical University

摘　　要：目的为了探讨门脉高压性胃病的发病机理及肝硬化病人术后再出血的原因。方法设计了肝硬化门脉高压大鼠模型，并对其实施常规贲门周围血管离断术，观察了断流手术前后大鼠胃粘膜功能及形态学变化的特点。结果肝硬化门脉高压大鼠胃粘膜屏障功能受到严重削弱，组织形态学变化亦更具特征型。结论贲门周围血管离断术后胃粘膜防御能力进一步削弱，术后胃粘膜病变发生率高，是术后再出血的原因之一。Objective In order to explore the pathogenesis of PHG and the causes of rebleeding after portoagyous disconnection in cirrhotic patients.Methods We have observed the functional and morphological changes of gastric mucosa before and after operation.Results It shows that the barrier capability of gastric mucosa with portal hypertension is seriously damaged, and the morphological changes are even characteristic. Conclusion The results suggest that the gastric mucosal barrier capability is further defected post operatively, and the incidence of gastric mucosal lesion and ulceration is higher after portoagyous disconnection, and it is one of the causes of rebleeding.

关 键 词：肝硬化 门脉高压症 断流术 大鼠 

分 类 号：R575.205[医药卫生—消化系统] R657.340.5[医药卫生—内科学]