复发性单纯疱疹性角膜炎患者外周血T-淋巴细胞亚群变化与SIL-2R水平的关系  

Relationship between T-lymphocyte subpopulation and soluble interleukin-2 receptor (SIL-2R) in recurrent herpetic keratitis

作　　者：张华[1,2,3] 宋宏文[1,2,3] 迟福昌[1,2,3] 王志安 郭绒霞[1,2,3] 孙乃学 

机构地区：[1]山东省济宁市第一人民医院 [2]西安医科大学 [3]西安医科大学第二临床医学院

出　　处：《中华实验和临床病毒学杂志》1998年第1期67-69,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的研究复发性单纯疱疹性角膜炎患者外周血Ｔ－淋巴细胞亚群变化与血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）水平的关系。方法测定了３０例复发性单纯疱疹性角膜炎患者外周血Ｔ－淋巴细胞亚群，同时用酶联免疫吸附试验检测ＳＩＬ－２Ｒ水平。结果复发性单纯疱疹性角膜炎患者ＣＤ３、ＣＤ４／ＣＤ８均值与正常对照组相比明显降低；ＳＩＬ－２Ｒ与对照组比较显著增高。结论复发性单纯疱疹性角膜炎患者体内免疫功能低下，ＳＩＬ－２Ｒ水平升高可能是其原因之一，这也为免疫治疗提供了一定依据。This article is to study the relationship between T-lymphocyte subpopulation and soluble interleukin-2 recepeor (SIL-2R)in recurrent herpetic keratitis.We detected the T-lymphocyte subpopulation of peripheral blood and soluble interleukin-2 receptor(SIL-2R)in 30 cases of recurrent herpetic keratitis, 25 cases of healthy people were set as contrast. The results showed that there were obvious decrease and of CD3、CD4/CD8, and magnificant elevation of soluble interleukin-2 receptor(SIL-2R)in sera of recurrent herpetic kevatitis cases when compared with the contrasts.we hold that the lower immune function in recurrent herpetic keratitis cases may attribute to the high level of soluble interleukin-2receptor(SIL-2R)in the serum.The discovery can provide foundation for immunotherapy.

关 键 词：单纯疱疹病毒 角膜炎 T淋巴细胞亚群 SIL-2R 

分 类 号：R772.21[医药卫生—眼科]