激光立体成形镍铬烤瓷合金的生物安全性评价  

Biological safety of Ni-Cr alloy fabricated by laser solid forming technology

作　　者：贾艳[1] 高勃[1] 

机构地区：[1]第四军医大学口腔医学院修复科,西安710032

出　　处：《第三军医大学学报》2009年第8期668-671,共4页Journal of Third Military Medical University

基　　金：国家高技术研究发展计划(863计划)(2002AA336050)~~

摘　　要：目的评价激光立体成形Ni-62.9Cr-23烤瓷合金的生物安全性。方法参照GB/T16886-2003和YY/T0279-1995以及YY/T0244-1996标准对激光立体成形镍铬烤瓷合金进行4种体内外实验,即细胞毒性实验、短期全身毒性实验、溶血实验及口腔黏膜刺激实验。结果激光立体成形Ni-62.9Cr-23烤瓷合金细胞毒性实验评级为0～1级,无明显细胞毒性作用,未见任何短期全身毒性反应,溶血程度为0.385%,口腔黏膜刺激实验未见异常组织学反应。结论由以上结果可以初步认为激光立体成形Ni-62.9Cr-23烤瓷合金具有良好的生物安全性,是一种理想的生物材料。Objective To evaluate the biological safety of a Ni-62.9Cr-23 alloy fabricated by laser solid forming technology. Methods According to the requirements of national standards GB/T16886-2003, YY/ T0279-1995 and YY/T0244-1996, general eytotoxicity, acute systemic toxicity, hemolysis testing, oral mucous membrane irritation testing were used to evaluate the alloy. Results The alloy was indicated having no tyrotoxicity and with a hemolytic rate of 0. 385%. The oral mucous membrane irritation testing showed that the alloy had no mucous membrane irritation. The acute systemic toxicity test indicated that the alloy had no acute sys- temic toxicity. Conclusion The Ni-62.9Cr-23 alloy has good biological safety in a certain extent.

关 键 词：激光立体成形 镍铬合金 生物安全性 牙科材料 

分 类 号：R783.1[医药卫生—口腔医学] R991[医药卫生—临床医学]