霍奇金淋巴瘤转染mtrⅡ基因后ki67的表达及其意义  

Expression of ki67 in Hodgkin's disease cell lines transfected by mtrⅡ gene

作　　者：王星[1] 林雨冬[1] 王明元[1] 吴德柱[1] 王煜[1] 杜京丽[1] 

机构地区：[1]南京军区福州总医院95临床部外科,福建省莆田巿351100

出　　处：《实用医学杂志》2009年第7期1020-1021,共2页The Journal of Practical Medicine

基　　金：福建省自然科学资助项目(编号:C0410048)

摘　　要：目的:探讨ki67在转染mtrⅡ基因后的霍奇金淋巴瘤中的表达情况及其意义。方法:将mtrⅡ转染人霍奇金淋巴瘤细胞系,采用免疫组化法检测转染前后ki67的表达情况。结果:未转染mtrⅡ基因的ki67阳性率为21.3%,转染mtrⅡ基因后ki67的阳性率为36.8%,两者之间差异具有统计学意义(P<0.05)。结论:mtrⅡ基因可能参与了霍奇金淋巴瘤恶性转化的过程。Objective To explore the expression and significance of ki67 in Hodgkin＇s disease cell llines transfected by mtr Ⅱ gene. Methods The expression of ki67 in Hodgkin＇s disease cell lines which had been transfected by mtr Ⅱ gene were measured by immunohistochemical technique. Results The expression rate of ki67 in Hodgkin＇s disease cell lines which were transfected by mtr Ⅱ gene was higher than that in those weren＇t transfected by mtr Ⅱ gene （P 〈 0.05）. Conclusion mtr Ⅱ gene may be related to the progress of Hodgkin＇s disease.

关 键 词：霍奇金病 mtrⅡ基因 KI67基因 

分 类 号：R733.1[医药卫生—肿瘤] R733.4[医药卫生—临床医学]