食管鳞癌中趋化因子受体CCR7、COX-2的表达与淋巴结转移的关系  

The relationship between the expressions of CCR7、COX-2 and the lymphnode metastasis of esophageal squamous cell carcinoma

作　　者：刘建伟[1] 赵国昌[1] 

机构地区：[1]河南省新乡医学院第一附属医院胸外科,453100

出　　处：《中国现代药物应用》2009年第8期39-40,共2页Chinese Journal of Modern Drug Application

摘　　要：目的研究食管鳞癌中趋化因子受体CCR7、COX-2的表达与浸润转移的关系。方法用免疫组化S-P法检测了117例食管鳞癌患者中CCR7、COX-2的表达。结果CCR7在淋巴结转移组的阳性表达率为72.6%(53/73),而在非转移组的阳性表达率为34.1%(15/44),两组之间差异显著(P<0.05)。COX-2在淋巴结转移组的阳性表达率为65.8%(48/73),而在非转移组阳性表达率为38.6%(17/44),两组之间亦具有显著差异(P<0.05)。结论趋化因子受体CCR7和COX-2的表达均与食管鳞癌浸润密切相关。Objective To explore the relationship between the expressions of chemokine receptor CCRT,cyclooxygenase-2 （COX-2）and the infiltration and metastasis of esophageal squamous cell carcinoma. Method Using labbelled Streptavidin-Biofin （S-P） technique, we examined the expressions of CCRT, COX-2 in 117 cases with esophageal squamous cell carcinomas specimens. Results In the cases with metastasis the positive rate of CCR7 was 72.6% （53/73）, but in the cases with non-metastasis the positive rate was 34. 1% （ 15/44）, there was a significant difference between the two groups （ P 〈 0. 05 ）. The positive rate of COX-2 expression was 65.8 % （48/73） in the lymph node metastasis group, and 38. 6% （17/44） in non-metastas group , Conclusion there was a significant difference between the two groups （ P 〈 0. 05 ）. Conclusion The expressions of chemokine receptor CCR7 ,cyclooxygenase-2 （COX-2） were intimate correlation with the infiltration and metastasis of esophageal squamous cell carcinoma.

关 键 词：食管鳞癌 CCR7 COX-2 淋巴结转移 

分 类 号：R735.1[医药卫生—肿瘤]