Survivin、P16和CyclinD1在卵巢癌的表达及临床意义  

Expression of Survivin,P16 and CyclinD1 in ovarian epithelial tumors and their clinical significances

作　　者：冷丽丽[1,2] 郑建华[1] 

机构地区：[1]哈尔滨医科大学,硕士研究生161005 [2]齐齐哈尔市第一医院妇产科

出　　处：《齐齐哈尔医学院学报》2009年第3期257-258,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨卵巢上皮性癌组织中抑凋亡蛋白Survivin,P16基因和细胞周期素蛋白Cy-clinD1的表达及临床意义。方法采用免疫组织化学SABC法检测18例良性卵巢肿瘤、20例交界性卵巢肿瘤、58例卵巢上皮性癌及10例正常卵巢组织中的Survivin,P16和CyclinD1表达及其与临床病理的关系。结果Survivin在上皮性卵巢良性肿瘤,交界性肿瘤和恶性肿瘤组织中的检出率为:16.7%、40.0%、62.1%,在正常卵巢组织无阳性表达。P16蛋白在正常卵巢组织中的检出率为80.0%,卵巢良性肿瘤,交界性肿瘤,恶性肿瘤的检出率分别为:61.1%、50.0%、22.4%。CyclinD1在正常卵巢组织中的检出率为10.0%,卵巢良性肿瘤,交界性肿瘤和恶性肿瘤组织中CyclinD1蛋白的阳性检测率分别为27.8%、45.0%、58.6%。结论对Survivin,P16和CyclinD1表达的检测有助于判断卵巢癌预后,指导临床治疗,并为基因治疗提供理论依据。Objective To investigate the expression of Survivin,p16 and CyclinD1 in ovarian epithelial tumors and their clinical significances. Methods Using immunohistochemical method SABlE,the author examined Survivin,pl 6 and CyclinD1 in 18 cases benign, 20 borderline, 58 malignant tumors and 10 normal ovarian tissues. Results The expression of Survivin in ovarian epithelial tumors, benign tumor, borderline tumor, malignant tumor tissue was 16.7 %,40.0 %,62.1%, the expression of Survivin in normal ovarian has no connection. The expression of Survivin in normal ovarian,ovarian epithelial benign tumor,borderline tumor and malignant tumor tissue was 80.0% ,61.1% ,50.0% and 22.4%, respectively. The expression of CyclinD1 in ovarian epithelial tumors, benign tumor, borderline tumor, malignant tumor and normal ovarian tissue was 27.8% ,45.0% ,58.6% and 10.0%. Conclusions Measurement of the expression of Survivin, P16 and CyclinD1 in patients＇ tumors might help in predicting prognosis,directing clinical treatment and providing theories for genetic therapy.

关 键 词：卵巢肿瘤 SURVIVIN P16抑癌基因 CYCLIND1 原癌基因 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤] R735.7[医药卫生—临床医学]