关节病型银屑病与HLA-DRB1等位基因相关性研究  

Research on the association between HLA-DRB1 locus alleles and psoriatic arthritis in Shandong Han Population

作　　者：张福仁[1] 屈丽娜[1] 杨宝琦[1] 朱传福[2] 田洪青[1] 

机构地区：[1]山东省皮肤病性病防治研究所,济南250022 [2]山东省血液中心

出　　处：《中国麻风皮肤病杂志》2009年第4期233-235,共3页China Journal of Leprosy and Skin Diseases

基　　金：山东省科技攻关项目(2007GG10002016)

摘　　要：目的:探讨HLA—DRB1等位基因与山东汉族关节病型银屑病(PsA)及其临床类型的相关性。方法:应用聚合酶链反应-寡核苷酸探针杂交分型法(PCR-SSOP)对42例山东汉族PsA(病例组)与90例健康献血者(对照组)进行HLA-DRB1等位基因分型。结果:42例PsA患者组中共检测到13对HLA-DRB1等位基因,未发现与PsA及其临床类型相关的HLA-DRB1等位基因,DRB1*12(P=0.036)等位基因出现的频率明显低于对照组,但经校正后无显著性差异。结论:HLA-DRB1等位基因可能与山东汉族PsA及其临床类型无关,对PsA的分型及预后价值有限。Objective： To explore the association between HLA-DRB1 locus alleles and psoriatic arthritis in Shandong Han population. Methods： Polymerase chain reaction- sequence specific oligonucleotide probes （PCR- SSOP） method was used to genotype HLA- DRB1 alleles in 42 consecutive PsA patients and 90 healthy controls of Shandong Han nationality. Results： No definite association was found between HLA- DRB1 alleles and PsA or its chnical subtype, while the antigens DRB1 ＊ 12 alleles were found in a low frequency in PsA compared with healthy controls （ P = 0.036）, but the difference was not significant when the alleles＇ number was tetod. Conclusion： HLA - DRB1 locus alleles have limited value on accurate grouping and prognosing for PsA.

关 键 词：银屑病型关节炎 等位基因 HIA分型 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]