环糊精包合作用诱导聚合物自组装的研究进展  

Polymer self-assembly induced by cyclodextrin inclusion in solution

作　　者：黄进[1] 任丽霞[2] 范红蕾[1] 陈永明[1] 

机构地区：[1]武汉理工大学化学工程学院,武汉430070 [2]中国科学院化学研究所,高分子物理与化学国家重点实验室,北京100190

出　　处：《中国科学（B辑）》2009年第4期301-314,共14页Science in China(Series B)

基　　金：国家自然科学基金(批准号:20404014)资助

摘　　要：将主客体识别与聚合物自组装相结合,利用环糊精对聚合物的包合作用在溶液中诱导聚合物组装形成结构可控的纳米粒子,形成有别于基于环糊精/聚合物包合作用形成的结晶粉末和超分子水凝胶的新型材料.本文介绍了这种诱导组装方案的研究背景及最新的研究成果,综述了诱导组装的原理、特点及影响因素.研究表明,由这种方案制备的聚合物纳米粒子具有超分子动态可逆的特征,进而显示出对温度和pH等敏感的性质.该类环糊精包合作用诱导组装的聚合物超分子聚集体在生物医学材料方面具有潜在的应用价值,如用作药物和基因的可控传递释放载体.Based on a combination of host-guest recognition and polymer self-assembly, the inclusion of cyclodextrin to polymer segment has been used to induce the assembly of polymer in solution, and hence produce me well-defined polymer nanoparticles. This kind of nanoparticles is a new form of materials besides crystalline powders and supramolecular hydrogels based upon cyclodextrin/polymer interaction. In this review, the backgrounds and recent progress of cyclodextrin-induced polymer assembly were introduced. Therefore, the principle and uniqueness of such induced-assembly strategy were concluded. Furthermore, the supramolecular structure of polymer nanoparticles resulted in a stimulus-response property. This kind of novel supramolecular polymer aggregates based on cyclodextrin inclusion showed a potential as biomedical materials, and especially as the carriers of drug and gene with controlled delivery and release function.

关 键 词：环糊精 聚(准)轮烷 包合作用 聚合物 自组装 

分 类 号：O631.3[理学—高分子化学]