C反应蛋白基因-717A/G多态性与老年缺血性脑卒中的相关分析  

Study on association between-717A/G polymorphism of the CRP gene and ischemic stroke in elderly subjects

作　　者：刘志忠[1] 丁秀荣[2] 郑华光[1] 王瑞珉[1] 张果[1] 康熙雄[1] 

机构地区：[1]首都医科大学附属北京天坛医院,北京100050 [2]华北煤炭医学院附属医院

出　　处：《中华老年心脑血管病杂志》2009年第4期269-271,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家科技部"863"重点基金(2006AA020706)

摘　　要：目的探讨C反应蛋白(CRP)基因-717A/G多态性与老年缺血性脑卒中的关系。方法选择年龄≥60岁的缺血性脑卒中患者196例为脑卒中组,同期健康体检者197例为对照组,PCR-RFLP方法检测CRP基因型,并测血清高敏CRP(hs-CRP),logistic回归分析CRP与缺血性脑卒中的关系。结果脑卒中组hs-CRP显著高于对照组(p<0.01),两组CRP基因-717A/G多态性分布无统计学差异(P>0.05)。脑卒中组AA基因型患者hs-CRP浓度显著高于AG+GG基因型[2.30(0.95～3.45)mg/L vs 1.05(0.61～2.12)mg/L,P<0.01],但时照组不同基因型hs-CRP浓度无统计学差异。hs-CRP是老年缺血性脑卒中发生的独立危险因素。结论血清hs-CRP浓度升高与老年脑卒中相关。CRP基因-717A/G多态性与老年缺血性脑卒中无相关性,但与血清hs-CRP浓度有关。Objective To investigate the association between-717A/G polymorphism of C-reactive protein（CRP） gene and risk for ischemic stroke in elderly subjects. Methods Polymerase chain reaction-restriction fragment length polymorphism was used for detection of CRP genotypes in 196 older patients with ischemic stroke and 197 controls. Serum hs-CRP levels were measured by routine method. Association of CRP-717A/G polymorphism and ischemic stroke was analysed by logistic regression analysis. Results Serum CRP level of the patients with ischemic stroke was significantly higher than that of the controls. The distribution of CRP gene-717A/G polymorphism did not show significant difference between ischemic stroke and control groups. In patients, the serum CRP levels were significantly higher in AA individuals than in AG＋ GG individuals [2.30（0.95-3.45） mg/L vs 1.05（0.61-2. 12） rag/L, P 〈 0.01]. The CRP-717A/G polymorphism did not influence CRP levels in controls. Conclusion Increased serum CRP levels is associated with ischemic stroke in the elderly. CRP-717A/G polymorphism is not associated with ischemic stroke. However,the polymorphism may affect serum CRP levels in stroke patients.

关 键 词：C反应蛋白质 脑血管意外 多态性 限制性片段长度 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.160.5[医药卫生—临床医学]