柴胡牛蒡汤加减治疗亚急性甲状腺炎的临床研究  

Treatment of subacute thyroiditis with modified Chaihuniubang Decoction

作　　者：夏仲元[1,2] 任卫华[2] 庞洁[2] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]中日友好医院中医外科

出　　处：《北京中医药大学学报》2009年第3期208-211,共4页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：目的探讨中药柴胡牛蒡汤加减治疗亚急性甲状腺炎的临床疗效及其安全性。方法将150例亚急性甲状腺炎患者随机分为中药柴胡牛蒡汤加减治疗组100例,西药芬必得对照组50例。观察8周,停药后随访3个月,比较两组症状体征改善时间、疗效、疗程、安全性、甲减发生率和复发率。结果中药治疗组有效率100%,西药对照组有效率94%,两组比较有显著性差异(P<0.05)。中药治疗组甲状腺疼痛、肿大起效时间分别为(7.14±0.13)d和(8.90±0.59)d,与西药对照组比较有显著性差异(P<0.05)。中药治疗组退热时间与西药对照组比较无显著性差异(P>0.05)。中药治疗组疗程(37.85±0.89)d,西药对照组(47.33±1.35)d,两组比较有显著性差异(P<0.05)。随访3个月,中药治疗组甲减发生率为16%,西药对照组为28%;中药治疗组无1例复发,西药对照组2例复发。中药治疗组未发现不良反应。结论中药柴胡牛蒡汤加减治疗亚急性甲状腺炎具有良好的临床疗效,疗程短,甲减发生率及复发率低,无明显不良反应。Objective To investigate the curative effect and safety of modified Chaihuniubang Decoction for treating subacute thyroiditis.Method All patients（n=150） with subacute thyroiditis were randomly divided into the treatment group treated with modified Chaihuniubang Decoction（n=100） and the control group treated with Ibuprofen Capsules（n=50）.Two groups were observed for 8 weeks and followed up for 3 months after the treatment stopped.The time for relieving symptoms and signs,curative effects,treatment course,safety and incidence rate and recurrent rate of hypothyroidism were compared in two groups.Result The effective rate of the treatment group was 100% and that of the control group,94%.There was a significant difference between two groups（P〈0.05）.In the treatment group the time for relieving pain and swelling of thyroid gland was（7.14±0.13） days and（8.90±0.59） days respectively with a significant difference compared to the control group（P〈0.05）.There was no significant difference in defervescence time between two groups（P〉0.05）.The treatment course was（37.85±0.89） days in the treatment group and（47.33±1.35） days in the control group with a significant difference（P〈0.05）.The result of follow-up showed that the incidence rate of hypothyroidism was 16% in the treatment group and 28% in the control group,and the treatment group had no recurrent case and the control group had 2 recurrent cases.The adverse reaction was not observed in the treatment group.Conclusion Modified Chaihuniubang Decoction has a good curative effect on subacute thyroiditis with a shorter treatment course,lower incidence rate and lower of recurrent rate of hypothyroidism,and without obvious adverse reaction.

关 键 词：亚急性甲状腺炎 柴胡牛蒡汤加减 临床研究 

分 类 号：R653[医药卫生—外科学]