微波辐射在合成沙利度胺的铵盐类衍生物中的应用  

Application of the microwave-assisted method in synthesis of thalidomide amino acid derivatives

作　　者：郭举[1] 郑永胜[1] 郭栋[1] 汪宏[1] 于姝燕[1] 杨跃[1] 田之悦[2] 罗娟[2] 成丽[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学化学学院,四川成都610065

出　　处：《化学研究与应用》2009年第4期582-586,共5页Chemical Research and Application

基　　金："863课题"(05H055)资助项目

摘　　要：Amino acid benzyl ester p-toluenesulfonic acids were synthesized under microwave irradiation condition by reaction of four amino acids with benzyl alcohol and p-toluenesulfonic acid,and then reacted with the N-phthaloyl-L-glutamic anhydride to yield compound 3a-d,hydrogenised and treated with NH3(g) to obtain the target compounds—thalidomide ammonium salt derivatives.The microwave-assisted method was used to synthesis the thalidomide amino acid benzyl ester p-tolunensulfonic acid,the reaction time was brought down with improved yield as compared with conventional heating method.The structures were comfirmed by MS,1H-NMR and elemental analysis.Amino acid benzyl ester p-toluenesulfonic acids were synthesized under microwave irradiation condition by reaction of four amino acids with benzyl alcohol and p-toluenesulfonic acid,and then reacted with the N-phthaloyl-L-glutamic anhydride to yield compound 3a-d,hydrogenised and treated with NH3 （g） to obtain the target compounds--thalidomide ammonium salt derivatives. The microwave-assisted method was used to synthesis the thalidomide amino acid benzyl ester p-tolunensulfonic acid, the reaction time was brought down with improved yield as compared with conventional heating method. The structures were comtlrmed by MS, ^1H-NMR and elemental analysis.

关 键 词：微波辐射 氨基酸苄酯对甲苯磺酸盐 沙利度胺铵盐类衍生物 合成 

分 类 号：O621.3[理学—有机化学]