食管癌组织MRP1/CD9、ME491/CD63的表达与其生物学行为的关系  

Expressions and biologic action of MRP1/CD9 and ME491/CD63 in esophageal cancer

作　　者：季润元[1] 束晓明[2] 张徐宁[1] 李雪甫[1] 沈阳[3] 王成海[4] 冯振卿[5] 

机构地区：[1]江苏省淮阴卫生高等职业技术学校淮安市消化道肿瘤重点实验室,江苏淮安223300 [2]淮安市第一人民医院妇产科,江苏淮安223300 [3]淮安市第二人民医院病理科,江苏淮安223302 [4]扬州大学医学院病理教研室,江苏扬州225001 [5]南京医科大学病理学系,江苏南京210029

出　　处：《临床和实验医学杂志》2009年第4期9-11,共3页Journal of Clinical and Experimental Medicine

基　　金：江苏省卫生厅医学科技发展基金立项(J200611)

摘　　要：目的探讨食管癌组织中MRP1/CD9、ME491/CD63表达的临床意义及其与生物学行为的关系。方法应用免疫组化SABC法,检测54例食管癌组织中MRP1/CD9、ME491/CD63的表达,并进行比较分析。结果食管癌组织MRP1/CD9的表达与淋巴结转移、肿瘤的分级、术后存活时间显著相关(P<0.05)。ME491/CD63表达的与食管癌转移、分化、浸润深度、术后生存时间无相关性(P>0.05)。结论MRP1/CD9可作为食管癌的预后指标。Objective To investigate the clinical significance and the biologic action of MRP1/CD9 and ME491/CD63 expressions in e- sophageal cancer. Methods SABC immunohistochemistry was used to examine the expressions of MRPI/CD9 and ME491/CD63 in 54 tissue sampies obtained from 54 eases of esophageal cancer. Results The expression of MRP1/CD9 in esophageal cancer tissues was significantly correlated with lymph node metastasis, the stage of tumor and survival time after surgery （ P 〈0.05）. No correlation was found between the expression of ME491/CD63 and metastasis, differentiation,invasive depth, and survival time postoperation. Conclusion MRP1/CD9 may be a prognostic factor of esophageal cancer.

关 键 词：MRP1/CD9 ME491/CD63 食管癌 生物学行为 

分 类 号：R735.1[医药卫生—肿瘤] R735.2[医药卫生—临床医学]