TACE、PEI双介入间隔疗法治疗晚期原发性肝细胞癌临床观察  

Clinical observation of treating the primary hepatocellular carcinoma in the advanced stage by using TACE and PEI

作　　者：钟立清[1] 徐寅聪[1] 陆龙辉[1] 孟凡龙[1] 

机构地区：[1]解放军第123医院放射科,蚌埠233015

出　　处：《白求恩军医学院学报》2009年第2期69-71,共3页Journal of Bethune Military Medical College

摘　　要：目的对照观察肝动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)和经皮肝穿刺无水乙醇注射(percuta-neous ethanol injection,PEI)双介入间隔疗法治疗晚期原发性肝细胞癌(hepatocellular carcinoma,HCC)临床效果。方法观察组25例采用间隔2周进行TACE、PEI分别配合治疗,每疗程TACE2～3次、PEI 2～4次。对照组29例单纯进行TACE治疗。两组观察期3年。结果观察组1年内生存率与对照组相比无明显差异,2年、3年内生存率高于对照组(P<0.05);观察组肿瘤缩小总有效率高于对照组(P<0.05)。结论TACE、PEI间隔双介入疗法较单纯TACE治疗晚期原发性肝细胞癌能够提高治疗效果,延长患者存活时间,改善生存质量。Objective To comparatively observe the clinical efficacy of transcatheter arterial chemoembolization（TACE） combined with percutaneous ethanol injection （PEI）in the treatment of primary hepatocellular carcinoma （HCC） in the advanced stage. Methods The observation group （25 cases） were treated with TACE and PEI with intervals about two weeks. Each course of treatment included 2 to 3 times of TACE and 2 to 4 times of PEI.The control group （29 cases） were treated only with TACE. All the two groups were observed for 3 years. Results The survival rate of the two groups had no remarkable difference in one year, but the survival rate of observation group was higher than that of the control group in two or three years（ P 〈 0.05）. The total effective rate of tumor reduction in the observation group was higher than that of the control group（ P 〈 0.05）. Conclusion Compared with the single TACE treatment, TACE combined with PEI treatment for the advanced primary HCC can improve the therapeutic efficacy and extend the survival time and improve the quality of life of patients.

关 键 词：原发性肝细胞癌 肝动脉化疗栓塞术 经皮肝穿刺无水乙醇注射 

分 类 号：R735.7[医药卫生—肿瘤]