选择素在人脑胶质瘤中的表达及意义  

The Expression and Significance of Different Selectins in Human Gliomas

作　　者：傅军[1] 张成生[1] 张一[2] 周幽心[3] 

机构地区：[1]内江市第一人民医院神经外科,四川内江641000 [2]苏州大学附属第三医院,江苏常州213003 [3]苏州大学附属第一医院,江苏苏州215006

出　　处：《肿瘤基础与临床》2009年第2期109-111,共3页journal of basic and clinical oncology

摘　　要：目的通过检测E选择素、P选择素、L选择素在人脑胶质瘤中的表达，探讨其与胶质瘤浸润发展的关系。方法采用免疫组织化学S-P法分别检测E选择素、P选择素、L选择素在61例人脑胶质瘤和8例正常人脑组织中的表达。结果E选择素、P选择素在胶质瘤组中的阳性表达率分别为60.7%、57.4%，较对照组明显增高（P〈0.05），而L选择素在胶质瘤组和对照组中的阳性表达率分别为57.4%、50.0%，比较差异无统计学意义（P（0.05）。E选择素在胶质瘤Ⅰ-Ⅱ级组和Ⅲ-Ⅳ级组中的阳性表达率分别为46.9%、75.9%，随肿瘤级别增高表达水平也明显增高（P（0.05），P选择素、L选择素在不同级别胶质瘤中的阳性表达率比较差异无统计学意义（P（0.05）。结论E选择素、P选择素可能与人脑胶质瘤的浸润发展有关。Objective To investigate the expression of E-selectin,P-selectin,L-selectin in gliomas and the relation between the selectins and gliomas. Methods The expression of E-selectin, P-selectin, L-selectin are detected in parrafin sections by using S-P immunohistochemical method. Results The positive expression rate of E-seleetin and P-selectin in gliomas are significantly higher than in control group （P 〈 0.05 ） , and also the expression rate of E-selectin in gliomas of grade Ⅰ -Ⅱ are significantly lower than that in gliomas of grade Ⅲ- Ⅳ （P 〈 0.05）. But there is no difference of the expression of L-selectin in gliomas and control group（P 〉 0.05）. Conclusion E-selectin,P-selectin may be correlated to the oncogenisis and progression of gliomas and there is no relation between the L-selectin and glioma.

关 键 词：选择素 胶质瘤 浸润 

分 类 号：R739.41[医药卫生—肿瘤]