Aurora A在食管鳞癌组织中的表达及意义  

The Expressions of Aurora A in Human Esophageal Squamous Cell Carcinoma

作　　者：钟亚莉[1] 童彤[2] 詹启敏[2] 杨观瑞[3] 唐芙爱[1] 

机构地区：[1]郑州大学第二附属医院消化内科,河南郑州450003 [2]中国医学科学院肿瘤研究所分子肿瘤学国家重点实验室,北京100210 [3]河南省医学科学研究所,河南郑州450052

出　　处：《肿瘤基础与临床》2009年第2期111-113,共3页journal of basic and clinical oncology

摘　　要：目的通过对Aurora A在人食管鳞癌组织中的表达研究,探讨其与食管癌的关系。方法应用免疫组织化学法及Westernblot分析食管鳞癌及癌旁组织中Aurora A的表达。结果64例食管鳞癌(ESCC)组织标本中70%(45/64)有阳性着色,61例癌周正常组织中不足2%(1/61)呈现阳性着色,ESCC组织和癌周正常组织中Aurora A的表达比较差异有统计学意义(P<0.01)。20对ESCC组织和癌周正常组织中的Western blot显示,12例(60%)ESCC组织中Aurora A的蛋白表达水平远远高于其癌旁组织。结论Aurora A在食管鳞癌中存在高表达。Objective To investigate the expressions of Aurora A in human esophageal squamous cell carcinoma（ESCC）. Methods Immunohistochemistry method and Western blot analysis were used to determine the expressions of Aurora A in ESCC samples and the normal adjacent tissues. Results Sixty-four ESCC tissues and sixty-one normal adjacent tissues were analyzed for Aurora A expressions and locations by immunohistochemical approach. Among sixty-four human ESCC samples,strong cytoplasmic staining of Aurora A protein was detected in forty-five tumors. In contrast, only one sample exhibited strong staining for Aurora A protein among normal adjacent tissues（P 〈 0.01 ）. Protein of twenty tumor samples and their normal adjacent tissues were assayed for Aurora A expressions by Western blot analysis. Aurora A over-expressions were detected in twelve tumor samples. Conclusion Over-expressions of Aurora A are detected in ESCC tissues. It may play an important role in the tumorigenesis of ESCC.

关 键 词：食管鳞癌 AURORA A 蛋白激酶 

分 类 号：R735.1[医药卫生—肿瘤]