c-Met、TIMP2在宫颈鳞癌中的表达意义及二者之间的相关性研究  

The Expression and Relation of c-Met and Tissue Inhibitor of Metalloproteinase2 in Cervical Carcinoma

作　　者：吴恒香[1] 周成军[2] 纪新强[3] 马端慧[1] 

机构地区：[1]济南市第一人民医院,山东济南250011 [2]山东大学第二医院,山东济南250011 [3]青岛大学附属医院,山东青岛266400

出　　处：《中国初级卫生保健》2009年第4期112-114,共3页Chinese Primary Health Care

摘　　要：目的研究c-Met与TIMP2在宫颈鳞癌组织中的表达意义,探讨二者之间的的相关性。方法采用免疫组化s-p法检测48例宫颈鳞癌、13例宫颈上皮内瘤样病变(CIN)、15例正常宫颈组织中c-Met和TIMP-2的表达。结果正常宫颈CIN和宫颈鳞癌组织中c-Met表达依次增高,宫颈癌的临床分期越晚c-Met表达越强。TIMP2表达CIN中高于正常组织,到宫颈鳞癌又呈下降趋势,临床分期越晚,表达越弱。有淋巴结转移组与无淋巴结转移组比较,c-Met表达增高,TIMP2表达降低。c-Met及TIMP2表达负相关(P=0.029),但相关关系不密切(r=0.251)。结论c-Met与宫颈鳞癌发生发展有关、TIMP2可能是宫颈鳞癌发展过程中的1个早期事件;c-Met、TIMP2表达显著负相关,二者可成为观察宫颈癌侵袭进展、转移及预后的指标。OBJECTIVE To investigate the expression and clinical significance and their relation of c-Metprotein and tissue inhibitor of metalloproteinase-2 （TIMP-2） in cervical carcinoma. METHODS The expression of c-Met and TIMP-2 were detected by sp immunohistochemistry method in 48 cervical careinoma tissues, 13 cervical intraepithelial neoplasm（CIN） tissues and 15 normal cervical epithelium and cervicitis tissues. RESULT The positive expression of c-Met increased remarkably from normal tissue to CIN and then to cervical carcinoma. The expression of c-Met was positively correlated with clinical stage and lymph node metastasis. In CIN tissue, the positive expression of TIMP was higher than those of normal cervical epithelium. The expression of TIMP2 decreased significantly with rise clinical stage and decreased significantly with lymphnode metastasis. CONCLUSION Over expression of c-Met facilitates the malignant progress of cervical carcinoma. The TIMP2 expression may be an early event in malignant transformation of cervical squamous ceils. The expression of c-Met is negative related to TIMP2 in cervical carcinoma.The c-Met and TIMp expressions might be useful factors of patients with cervical carcinoma.

关 键 词：宫颈鳞癌 c—Met TIMP2 免疫组织化学 相关研究 

分 类 号：R737.33[医药卫生—肿瘤]