丙肝患者HCV-RNA病毒载量和ALT浓度的关系研究  

Study correlation between HCV-RNA quantity and alanine transaminase

作　　者：王宽[1] 王敏[2] 

机构地区：[1]新乡市疾病预防控制中心,河南新乡453000 [2]深圳市东湖医院肝病所,深圳518000

出　　处：《河南预防医学杂志》2009年第2期83-84,共2页Henan Journal of Preventive Medicine

摘　　要：目的研究丙肝患者血清HCV-RNA含量和ALT浓度的关系。方法采用荧光定量PCR法检测296例疑似HCV感染患者的血清HCV-RNA,ELISA法检测抗-HCV,全自动生化分析仪测定ALT。结果296例血清标本中,HCV-RNA和抗-HCV均阳性155例,HCV-RNA阳性而抗-HCV阴性的9例,HCV-RNA阴性而抗-HCV阳性的67例。HCV-RNA含量和ALT浓度水平相关性不显著。结论HCV-RNA和抗-HCV的检测是诊断HCV-RNA感染的重要指标。但HCV-RNA含量和ALT浓度水平无明显相关。objective To study relationship between the HCV - RNA levels and ALT levels Methods Fluorescent Quantitative PCR methods were used to detect the quantify of HCV -RNA in 296 serum samples ,the concentrations of anti -HCV and ALT were detected by the ELISA and automatic biochemistry analyzer. Result Of 296 serum samples 155 were both positive of HCV - RNA and anti - HCV, 9 were only HCV - RNA positive, and 67 were only anti - HCV positive. The levels of ALT and HCV RNA were no statistically different. Conclusion Both HCV - RNA and anti - HCV methods are important to diagnosing HCV, but the levels of ALT and HCV RNA have no obvious correlation with the liver inflammation and fibrosis.

关 键 词：HCV—RNA定量 丙型肝炎 ALT 

分 类 号：R575[医药卫生—消化系统]