维生素B_(12)对肝硬化贫血患者血液影响的临床研究  

Clinical study about the therapeutic effect of Vitamin B_(12) on the blood index of patients with liver cirrhosis overlapped anemia

作　　者：张囡囡[1] 刘鹏[1] 赵丽娟 杨华秀[1] 陶英[1] 米绍平[1] 

机构地区：[1]泸州医学院附属中医医院肝胆内科,四川泸州646000 [2]山东省枣庄矿业集团滕南医院内二科

出　　处：《胃肠病学和肝病学杂志》2009年第4期322-323,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的观察维生素B12对肝硬化失代偿期伴中度贫血患者红细胞(RBC)、血红蛋白(Hb)、网织红细胞计数的影响。方法将肝硬化失代偿期伴中度贫血患者60例随机分成对照组30例,治疗组30例,分别给予基础保肝及联合维生素B12综合治疗,观测两组RBC、Hb及网织红细胞数值,分析维生素B12的治疗作用。结果治疗组治疗后RBC、Hb、网织红细胞与治疗前比较差异有统计学意义(P<0.01);治疗组与对照组治疗后比较RBC、Hb、网织红细胞计数差异有统计学意义(PRBC<0.05,PHb<0.01,P网织红细胞<0.01)。结论维生素B12可有效改善肝硬化失代偿期贫血症状。Objective To observe the therapeutic effect of Vitamin Bt2 on red blood cell （RBC）, haemoglobin （Hb） , retieulocyte count of patients with decompensated liver cirrhosis overlapped moderate anemia. Methods Sixty patients with decompensated liver cirrhosis overlapped moderate anemia were randomly divided into two groups, thirty cases in the control group and thirty patients in the treatment group . Two groups were both given basic treatment of liver and Vitamin B12 was applied to the treatment group additionally. Then the changes RBC, Hb and reticuloeyte count of two groups were observed. Results After the treatment, there were significant changes of RBC, Hb and reticuloeyte count in the treatment group（P〈0.01）. And significant differences of these three indexes were found between the treatment group and the control group （PRBC〈0.05, PHb〈0.01, Preticulocyte count〈0.01）. Conclusion Vitamin B12 can effectively improve the symptoms of patients with decompensated liver cirrhosis overlapped anemia.

关 键 词：肝硬化 贫血 维生素B12 红细胞 血红蛋白 网织红细胞计数 

分 类 号：R575.2[医药卫生—消化系统]