四氧化二氮中毒大鼠视神经视网膜形态的改变  

Nitrogen tetroxide poisoning of rats with optic nerve changes in retinal morphology

作　　者：仇长宇[1] 胡莲娜[1] 吴继华[2] 罗灵[1] 闫洪欣[1] 赵军[1] 麻南[1] 李志生[1] 

机构地区：[1]解放军306医院眼科同,中国北京市100101 [2]解放军306医院病理科,中国北京市100101

出　　处：《国际眼科杂志》2009年第4期666-667,共2页International Eye Science

基　　金：中国人民解放军总装医药卫生类基金资助项目(No.yy2003015)~~

摘　　要：目的:研究大鼠在四氧化二氮染毒后的视神经及视网膜的病理改变。方法:正常雄性Winstar大鼠,在相同的时刻将每只大鼠用15mg的四氧化二氮溶液ip染毒,分别于染毒后2h及染毒后1wk处死动物,立即完整取出眼球,置于甲醛溶液送病理检查,用光学显微镜对病理组织进行观察分析。结果:四氧化二氮染毒后2h的大鼠与正常大鼠的视神经及视网膜的病理形态无明显差异;四氧化二氮染毒后1wk的大鼠与正常大鼠的视神经及视网膜的病理形态也无明显差异。结论:15mg的四氧化二氮溶液ip染毒后2h及1wk大鼠的视神经及视网膜在病理形态上未发现明显的异常。AIM： To study the optic nerve and retina of the pathological changes after injecting N2O4 in rats.METHODS： The retina and the optic nerve of normal male mice and poisoned mice that were injected by N2O4 were studied by light microscope.RESULTS： There are no distinctive changes between the retina or optic nerve of poisoned mice and normal mice at two hours or one week after the mice were poisoned.CONCLUSION： There were no visible changes under light microscope between poisoned mice＇s retina or optic nerve bv 15ma N2O4 and normal mice＇s.

关 键 词：视网膜 视神经 大鼠 四氧化二氮 光学显微镜 

分 类 号：R779.13[医药卫生—眼科]