首乌软胶囊对D-半乳糖致亚急性衰老小鼠的实验研究  

Shouwu Soft Capsule of Experimental Research on D-galactose-induced Subacute Mice

作　　者：张忠华[1] 朱萱萱[1] 王淑云[1] 倪文彭[1] 吴旭同[1] 

机构地区：[1]江苏省中医院,江苏南京210029

出　　处：《中华中医药学刊》2009年第4期765-766,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省中医药管理局资助项目[苏中医科(2008)号k066]

摘　　要：目的:探讨首乌软胶囊对D-半乳糖致亚急性衰老小鼠的保护作用。方法:采用D-半乳糖小鼠亚急性衰老模型。小鼠颈背部皮下注射1.2%D-半乳糖溶液0.1mL/10g鼠重,连续造模40天,并以空白组作对照,观察首乌软胶囊对亚急性衰老小鼠脑、胸腺、脾指数、自由基代谢指标血清和脑组织中超氧化物歧化酶(SOD)和丙二醛(MDA)含量的变化。结果:D-半乳糖诱导的亚急性衰老小鼠脑、胸腺和脾的重量指数明显下降,SOD活性明显下降(P<0.01),MDA含量明显提高(P<0.01)等衰老改变,首乌软胶囊能够提高亚急性衰老小鼠脑、胸腺和脾的重量指数,提高血清和脑组织中SOD(P<0.01)活性,降低MDA含量(P<0.01)。结论:首乌软胶囊具有一定的抗衰老作用,为临床提供了实验依据。Objective：to investigate the protective effects of Shouwu soft capsule on D-galactose-induced subacute mice. Methods： adopt D-galactose-induced subacute mice model. Hypodermic injectl. 2% D-galactose liquor（0.1mL/ 10g） by the nape of mice for 40 days. Observe：the ponderal index of brain, thoracic gland and spleen and the content variation of SOD and MDA in blood serum and brain tissue. Results The ponderal index of brain, thoracic gland and spleen and SOD activity are significantly decreased,while the MDA content increased（ P 〈 0. 01 ） in D-galactose-induced subacute mice. Shouwu soft capsule can improve the ponderal index of brain, thoracic gland and spleen and the SOD activity in blood serum and brain tissue and reduce MDA content. （ P 〈 0. 01 ）. Conclusion ： Shouwu soft capsule has a certain antiaging effect, to provide a clinical experimental basis.

关 键 词：首乌软胶囊 小鼠 衰老模型 器官指数 SOD MDA 

分 类 号：R-33[医药卫生]