小鼠胸腺组织细胞凋亡DNA电泳特征的观察  

The Characteristic of DNA Electrophoresis of Mice Thymocytes Apoptosis

作　　者：毕勇毅[1] 鲁德银[1] 喻伦银 杨晓茹 汪春红[1] 闫俊 邹祖玉 

机构地区：[1]基础医学院卫生学教研室

出　　处：《湖北医科大学学报》1998年第2期104-105,108,共3页

基　　金：湖北省科委基金

摘　　要：为了观察细胞凋亡后细胞基因组的特征性变化及其特点，应用地塞米松制备了在体小鼠胸腺组织细胞凋亡的模型，结果显示细胞ＤＮＡ经电泳后出现典型的梯形条带，尤以在地塞米松诱导６ｈ最为典型，且结果稳定，个体差异小。In this paper, mice thymocytes apoptosis were induced by dexanmethasone in vivo, and the DNA electrophoresis was used to detect DNA strand breaks. The results showed that were appearance of distincting “Ladder Pattern” of DNA fragments electrophoresis in agarose gel, especially in 6 hours after the steriod given.

关 键 词：细胞死亡 胸腺 电泳 小鼠 DNA 地塞米松 

分 类 号：R361.3[医药卫生—病理学]